Osthole Attenuates Doxorubicin-Induced Apoptosis in PC12 Cells through Inhibition of Mitochondrial Dysfunction and ROS Production

Figure 6

The effect of osthole on caspase-3 activity in PC12 cells. Cell pretreated with osthole 2 h before exposure to 5 μM of DOX. Caspase-3 activity was measured by colorimetric detection of p-nitroanilide and was expressed as percentage of control. Data are expressed as mean ± S.E.M of three separate experiments. ^###𝑃<0.001 versus control and ^∗∗∗𝑃<0.001 versus DOX-treated cells.