Evaluation of Inhibitory Effect of Recreational Drugs on Dopaminergic Terminal Neuron by PET and Whole-Body Autoradiography

Table 1

Biodistribution of accumulated radioactivity (%ID/g) in different tissues at the designed time points after administration of [¹⁸F]FDOPA in normal mice.

Radioactivity (% injection dose/tissue g)
Organs	2 min	15 min	30 min	60 min	120 min	240 min
Skin	0.06±0.030	0.44±0.140	0.47±0.220	0.36±0.510	0.33±0.070	0.31±0.060
Blood	0.12±0.000	0.62±0.170	0.58±0.110	0.45±0.080	0.31±0.060	0.13±0.040
Heart	0.07±0.020	0.63±0.270	0.51±0.020	0.43±0.060	0.28±0.040	0.16±0.050
Spleen	0.04±0.010	0.73±0.130	0.65±0.160	0.44±0.050	0.40±0.110	0.19±0.070
Stomach	0.28±0.090	1.07±0.300	1.15±0.080	0.91±0.150	0.78±0.170	0.47±0.060
Liver	0.06±0.040	0.87±0.210	0.87±0.160	058±0.180	0.34±0.090	0.16±0.060
Small intestine	0.09±0.030	0.87±0.200	1.01±0.210	1.13±0.190	0.56±0.220	0.20±0.040
Large intestine	0.05±0.020	0.57±0.170	0.60±0.320	0.49±0.110	0.39±0.040	0.21±0.050
Kidney	0.18±0.060	4.07±1.880	2.84±0.230	2.84±0.560	4.14±0.100	3.25±0.700
Bladder	0.04±0.020	3.75±2.240	7.88±5.220	4.51±1.850	11.25±3.960	2.30±0.850
Testis	0.02±0.010	0.37±0.180	0.40±0.080	0.28±0.020	0.26±0.260	0.16±0.100
Muscle	0.03±0.020	0.50±0.310	0.60±0.370	0.45±0.050	0.45±0.60	0.19±0.080
Bone	0.04±0.020	0.46±0.250	0.43±0.140	0.33±0.040	0.40±0.030	0.19±0.060
Brain	0.02±0.000	0.36±0.180	0.38±0.040	0.31±0.040	0.23±0.040	0.09±0.030

Data shown as average ± standard error of mean (𝑛=3 per time point).