Evaluation of Inhibitory Effect of Recreational Drugs on Dopaminergic Terminal Neuron by PET and Whole-Body Autoradiography

Table 3

Accumulation of [¹⁸F]FDOPA radioactivity in different imaging modalities in mice after treatment with recreational drugs.

Ketamine	PET	QWBAR
0 mg/kg	0.511±03080	0.523±0.082
35 mg/kg	0.120±0.022	0.114±0.044
45 mg/kg	0.078±0.005	0.026±0.025
55 mg/kg	0.085±0.012	0.041±0.015
Cocaine	PET	QWBAR
0 mg/kg	0.511±0.080	0.523±0.085
5 mg/kg	0.218±0.137	0.094±0.003
10 mg/kg	0.184±0.129	0.048±0.025
15 mg/kg	0.113±0.058	0.031±0.004
25 mg/kg	0.087±0.041	0.026±0.001
Methamphetamine	PET	QWBAR
0 mg/kg	0.511±0.080	0.523±0.082
2 mg/kg	0.341±0.114	0.093±0.115
5 mg/kg	0.179±0.058	0.068±0.053
10 mg/kg	0.097±0.006	0.048±0.022
15 mg/kg	0.088±0.023	0.035±0.023
20 mg/kg	0.055±0.023	0.026±0.115

Data shown as average ± standard error of mean (𝑛=3 per dose).