The Early Activation of CD8⁺ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector

Figure 3

The frequencies of early activated CD8⁺ T cells in the iLNs and MLN of WT and IFNAR2 KO mice following i.m. Adv vaccination. At 24 hours after the i.m. vaccination of 10¹⁰ vp of Ad-LacZ, the frequencies of CD69⁺ T cells in CD8⁺ T cells in the LNs of each mouse were measured by flow cytometry. Data are the pools of three independent experiments and are shown as the means ± S.E.M. (𝑛=6).^∗𝑃<0.001compared with the iLNs of PBS-administrated WT mice and MLN of Adv-administrated WT mice. ^#𝑃<0.0001 compared with other groups.