Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples

Figure 4

Overview of significant pathways in network marker of late stage bladder cancer. Among these KEGG pathways via DAVID tool (Table 5) showing a significant association with specific proteins of late stage bladder cancer, these molecular pathways are entitled with P value ≤ 0.05. It shows that these pathways are identified to play an important role in the carcinogenesis mechanism of late stage bladder cancer. The proteins in network markers of late stage bladder cancer highlighted by stars show potential targets in the pathways. Due to the different naming system, the same proteins in both these tables and in our text show the different names.

(a) The proteins in the late stage bladder cancer network marker are enriched in “hsa03010:Ribosome” (Rank 1 in Table 5)

(b) The proteins in the late stage bladder cancer network marker are enriched in “hsa03040:Ribosome” (Rank 2 in Table 5)

(c) The proteins in the early stage bladder cancer network marker are enriched in “hsa04120:Ubiquitin mediated proteolysis pathway” (Rank 3 in Table 5)