BioMed Research International / 2014 / Article / Fig 4

Research Article

Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer

Figure 4

Loss of function alterations affecting each complex component gene. The frequency of DNA sequence mutations (black), DNA copy-number loss (CNL, dark grey), and promoter methylation (light grey) affecting each complex gene is shown.