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BioMed Research International
Volume 2014, Article ID 159459, 10 pages
Research Article

Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer

BC Cancer Research Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver, BC, Canada V5Z 1L3

Received 11 February 2014; Accepted 26 May 2014; Published 9 July 2014

Academic Editor: Benjamin K. Tsang

Copyright © 2014 Victor D. Martinez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Alterations in the BTRC/SKP1/CUL1 complex A) DNA level alterations affecting genes involved in this BTRC/SKP1/CUL1 complex. We evaluated promoter hypermethylation (black), copy number losses (dark grey), and mutations (light grey) affecting BTRC, CUL1, GSK3A, GSK3B, and SKP1, as components of an alternative protein complex that might regulate NRF2 levels B) effects of DNA level alterations in the expression of GSK3A and SKP1 genes. Samples with no alteration (black) were compared with those exhibiting any alteration in the corresponding gene (red). Statistical comparison was performed using the Mann-Whitney test (“*” indicates a significant p-value).

  1. Supplementary Figure