Research Article
Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer
Table 1
Frequency of OVCA cases affected by individual genetic mechanisms.
| | Gene complex component | Sequence
mutation () | Copy-number loss
() | Hypermethylation
() |
| | CUL3 | 1 (0.3%) | 148 (26.01%) | 30 (5.15%) | | KEAP1 | 1 (0.3%) | 186 (32.69%) | 5 (0.86%) | | RBX1 | 0 (0%) | 464 (81.54%) | 41 (7.04%) |
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