BioMed Research International / 2014 / Article / Tab 1

Research Article

Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer

Table 1

Frequency of OVCA cases affected by individual genetic mechanisms.

Gene complex componentSequence 
mutation ( )
Copy-number loss 
( )
Hypermethylation 
( )

CUL3 1 (0.3%)148 (26.01%)30 (5.15%)
KEAP1 1 (0.3%)186 (32.69%)5 (0.86%)
RBX1 0 (0%)464 (81.54%)41 (7.04%)