BioMed Research International / 2014 / Article / Tab 1

Research Article

New Biomarkers to Predict the Evolution of In Situ Breast Cancers

Table 1

Expression of different markers in tumor cells and stroma in relation to lesion grade (G).

Markers Overall series
n = 44
(median, range)
G1 + G2
n = 23
(median, range)
G3
n = 21
(median, range)

TG2
 Tumor cells 10 (0–100) 20 (0–100) 3 (0–80)0.195
 Stroma 100 (0–100)100 (20–100) 100 (0–100)0.874
P < 0.0001**P < 0.0001**P < 0.0001**
HJURP
 Tumor cells 3.5 (0–100) 3 (0–100) 4 (0–80)0.582
 Stroma 0 (0–80) 0 (0–80) 0 (0–70)0.765
P = 0.006**P = 0.065**P = 0.027**
HIF-1α
 Tumor cells 0 (0–70) 0 (0–10) 3 (0–70)0.001
 Stroma 0 (0–10) 0 (0–10) 0 (0–10)0.732
P = 0.231**P = 0.172**P = 0.013**

values refer to the difference between tumor cell and stroma marker expression in G1 and G2 with respect to G3 lesions.
values refer to the difference between tumor cell and stroma marker expression within the same tumor grade and in the overall series.