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BioMed Research International
Volume 2014, Article ID 160505, 7 pages
http://dx.doi.org/10.1155/2014/160505
Research Article

Potential Role of Porcine Reproductive and Respiratory Syndrome Virus Structural Protein GP2 in Apoptosis Inhibition

1International Vaccine Center (VIDO-InterVac), Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK, Canada S7N 5E3
2Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5

Received 16 October 2013; Revised 16 December 2013; Accepted 17 December 2013; Published 9 January 2014

Academic Editor: Hanchun Yang

Copyright © 2014 Sujit Pujhari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Music and C. A. Gagnon, “The role of porcine reproductive and respiratory syndrome (PRRS) virus structural and non-structural proteins in virus pathogenesis,” Animal Health Research Reviews, vol. 11, no. 2, pp. 135–163, 2010. View at Google Scholar · View at Scopus
  2. E. J. Snijder, M. Kikkert, and Y. Fang, “Arterivirus molecular biology and pathogenesis,” The Journal of General Virology, vol. 94, part 10, pp. 2141–2163, 2013. View at Google Scholar
  3. T. Dokland, “The structural biology of PRRSV,” Virus Research, vol. 154, no. 1-2, pp. 86–97, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. L. C. Miller and J. M. Fox, “Apoptosis and porcine reproductive and respiratory syndrome virus,” Veterinary Immunology and Immunopathology, vol. 102, no. 3, pp. 131–142, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. T. S. Kim, D. A. Benfield, and R. R. R. Rowland, “Porcine reproductive and respiratory syndrome virus-induced cell death exhibits features consistent with a nontypical form of apoptosis,” Virus Research, vol. 85, no. 2, pp. 133–140, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. J.-H. Sur, A. R. Doster, and F. A. Osorio, “Apoptosis induced in vivo during acute infection by porcine reproductive and respiratory syndrome virus,” Veterinary Pathology, vol. 35, no. 6, pp. 506–514, 1998. View at Google Scholar · View at Scopus
  7. S.-M. Lee and S. B. Kleiboeker, “Porcine reproductive and respiratory syndrome virus induces apoptosis through a mitochondria-mediated pathway,” Virology, vol. 365, no. 2, pp. 419–434, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Costers, D. J. Lefebvre, P. L. Delputte, and H. J. Nauwynck, “Porcine reproductive and respiratory syndrome virus modulates apoptosis during replication in alveolar macrophages,” Archives of Virology, vol. 153, no. 8, pp. 1453–1465, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. S.-M. Lee and S. B. Kleiboeker, “Porcine arterivirus activates the NF-κB pathway through IκB degradation,” Virology, vol. 342, no. 1, pp. 47–59, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Luo, S. Xiao, Y. Jiang et al., “Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-β production by interfering with the RIG-I signaling pathway,” Molecular Immunology, vol. 45, no. 10, pp. 2839–2846, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Fu, R. Quan, H. Zhang, J. Hou, J. Tang, and W. H. Feng, “Porcine reproductive and respiratory syndrome virus induces interleukin-15 through the NF-κB signaling pathway,” Journal of Virology, vol. 86, no. 14, pp. 7625–7636, 2012. View at Google Scholar
  12. Y. J. Lee and C. Lee, “Porcine reproductive and respiratory syndrome virus replication is suppressed by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway,” Virus Research, vol. 152, no. 1-2, pp. 50–58, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Wang, R. Luo, L. Fang et al., “Porcine reproductive and respiratory syndrome virus (PRRSV) infection activates chemokine RANTES in MARC-145 cells,” Molecular Immunology, vol. 48, no. 4, pp. 586–591, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Yin, Y. Huo, Y. Dong et al., “Activation of c-Jun NH(2)-terminal kinase is required for porcine reproductive and respiratory syndrome virus-induced apoptosis but not for virus replication,” Virus Research, vol. 166, no. 1-2, pp. 103–108, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Luo, L. Fang, Y. Jiang et al., “Activation of NF-κB by nucleocapsid protein of the porcine reproductive and respiratory syndrome virus,” Virus Genes, vol. 42, no. 1, pp. 76–81, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Fang, L. Fang, Y. Wang et al., “Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation,” Virology Journal, vol. 9, article 83, 2012. View at Google Scholar
  17. A. Zakhartchouk, Y. Zhou, and S. K. Tikoo, “A recombinant E1-deleted porcine adenovirus-3 as an expression vector,” Virology, vol. 313, no. 2, pp. 377–386, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. V. Sanchez, M. Lucas, A. Sanz, and R. Goberna, “Decreased protein kinase C activity is associated with programmed cell death (apoptosis) in freshly isolated rat hepatocytes,” Bioscience Reports, vol. 12, no. 3, pp. 199–206, 1992. View at Google Scholar · View at Scopus
  19. M. E. Soriano and L. Scorrano, “The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis,” Advances in Experimental Medicine and Biology, vol. 687, pp. 97–114, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. B. J. Thomson, “Viruses and apoptosis,” International Journal of Experimental Pathology, vol. 82, no. 2, pp. 65–76, 2001. View at Publisher · View at Google Scholar
  21. D. Perez and E. White, “TNF-α signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K,” Molecular Cell, vol. 6, no. 1, pp. 53–63, 2000. View at Google Scholar · View at Scopus
  22. Y. M. Chung, K. J. Park, S. Y. Choi, S. B. Hwang, and S. Y. Lee, “Hepatitis C virus core protein potentiates TNF-α-induced NF-κB activation through TRAF2-IKKβ-dependent pathway,” Biochemical and Biophysical Research Communications, vol. 284, no. 1, pp. 15–19, 2001. View at Google Scholar
  23. C. H. Yang, A. Murti, S. R. Pfeffer, L. Basu, J. G. Kim, and L. M. Pfeffer, “IFNα/β promotes cell survival by activating NF-κB,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 25, pp. 13631–13636, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Bulfone-Paus, D. Ungureanu, T. Pohl et al., “Interleukin-15 protects from lethal apoptosis in vivo,” Nature Medicine, vol. 3, no. 10, pp. 1124–1128, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Inoue, J. Unsinger, C. G. Davis et al., “IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis,” The Journal of Immunology, vol. 184, no. 3, pp. 1401–1409, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. P. K. Vogt, “Retroviral oncogenes: a historical primer,” Nature Reviews Cancer, vol. 12, no. 9, pp. 639–648, 2012. View at Publisher · View at Google Scholar