The Role of Microclot Formation in an Acute Subarachnoid Hemorrhage Model in the Rabbit

Figure 4

In the SAH group, a significant reduction in CPP was observed within the first three minutes of the phase of maximum depletion compared to the baseline or the steady state (𝑃<0.001). A significant positive linear correlation between the mean CPP during the phase of maximum depletion after induced SAH and the total number of TUNEL positive cells was found in both the cortex (𝑟²=0.53, 𝑃=0.007; (a)) and the hippocampus (𝑟²=0.60, 𝑃=0.003; (b)). There was no correlation between CPP depletion and fibrinogen positive microvessels in either cortex (𝑟²=0.17, (c)) or hippocampus (𝑟²=0.22, (d)). Graphs include the 95% confidence intervals.

(a)  

(b)

(c)

(d)