Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat

Figure 1

Percent wakefulness, NREM and REM sleep amount in baseline, vehicle, lansoprazole (low dose), and lansoprazole (high dose) out of total recording time (TRT). Lansoprazole (both low and high dose) did not increase (a) wakefulness and (b) NREM sleep, significantly. However, (c) REM sleep amount significantly increased after high dose (10 mg/kg) of lansoprazole injection (𝑃<0.01; 𝐹_(3,27)=6.53) (one-way RM-ANOVA with Tukey post hoc tests) compared to vehicle (Tukey, 𝑃<0.01) and low dose (1 mg/kg) lansoprazole (Tukey, 𝑃<0.01) injections (i.p.). ** indicates 𝑃<0.01.

(a)

(b)

(c)