Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat

Figure 2

Percent REM sleep amount in baseline, vehicle, lansoprazole (low dose), and lansoprazole (high dose) groups during initial and later three hours of total recording time (TRT). (a) REM sleep amount did not change during the initial three-hour period after injection (𝑃=0.24; 𝐹_(3,27)=1.52) (one-way RM-ANOVA with Tukey post hoc tests), (b) it significantly increased, however, after three hours of lansoprazole injection (𝑃<0.05; 𝐹_(3,27)=4.07) (one-way RM-ANOVA with Tukey post hoc tests) compared to vehicle (Tukey, 𝑃<0.05) and low dose (Tukey, 𝑃<0.05). * indicates 𝑃<0.05.

(a)

(b)