Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat

Figure 3

REM sleep episode number, episode length and latency in vehicle, and lansoprazole low and high dose treated animals. (a) REM sleep episode number significantly increased in lansoprazole high dose (10 mg/kg) compared to vehicle and lansoprazole low dose (1 mg/kg) treated rats (𝑃<0.05; 𝐹_(2,20)=4.82). REM sleep episode duration length (b) and latency (c), however, did not change. * indicates 𝑃<0.05.

(a)

(b)

(c)