Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs

Table 3

Calculated ADME properties of compounds 1a–5a and 1b–5b.

Compound				MWt	HBDH	MNO	TPSA
1a	2.712	1.523	1.93	412.259	2	9	122.65
2a	3.346	2.077	1.69	448.292	2	9	122.65
3a	2.397	0.965	1.681	398.232	2	9	122.65
4a	2.997	2.08	2.173	426.286	2	9	122.65
5a	2.766	0.588	1.118	432.677	2	9	122.65
1b	0.542	−0.112	0.779	264.307	3	6	97.97
2b	1.168	0.676	0.633	300.341	3	6	97.97
3b	0.169	−0.681	0.487	250.28	3	6	97.97
4b	0.926	0.484	1.06	278.334	3	6	97.97
5b	0.811	−0.468	0.235	284.725	3	6	97.97