Trichostatin A Suppresses EGFR Expression through Induction of MicroRNA-7 in an HDAC-Independent Manner in Lapatinib-Treated Cells
Figure 2
HDAC3 and HDAC7 expressions were elevated to cause histone hypoacetylations in lapatinib-treated MDA-MB-231 cell. (a) and (b) Total lysates from parental and various lapatinib-treated MDA-MB-231 cells were subjected to Western blot analysis with indicated antibodies. (c) Total lysates from 231/Lap#6 cells transfected with specific HDAC3 or HDAC7 siRNA for 72 hours were subjected to Western blot analysis.
