Pathway-Driven Discovery of Rare Mutational Impact on Cancer

Figure 3

Single gene’s mutational influence on mRNA expression at gene level (X axis) and pathway level (Y axis). X: averaged gene expression difference of mutation having group minus nonhaving group). Y: averaged pathway level difference of mutation having group minus nonhaving group). Z: −log10p score, where p is from t-test of pathway statistics between mutated group versus nonmutated group. Red: mutation event where its influence on pathway level is significant (FDR q value < 0.1). Blue dots: mutation event where its influence on gene level is significant (FDR q value < 0.1) but not significant at pathway level.