Double-Bottom Chaotic Map Particle Swarm Optimization Based on Chi-Square Test to Determine Gene-Gene Interactions

Table 1

Estimated effect (odds ratio and 95% CI) from individual SNPs of 26 growth factor-related genes on the occurrence of breast cancer patients.

SNP; (Genes)^a	SNP; type	Case number/; normal number^a	Odds; ratio	95% CI
1. rs2237054; (EGF)	1-TT	4408/4418
	2-TA	570/569	1.00	0.89–1.14
	3-AA	22/13	1.70	0.85–3.37
2. rs5742678; (IGF1)	1-CC	2797/2866
	2-CG	1844/1837	1.03	0.95–1.12
	3-GG	359/297	1.24	1.05–1.46
3. rs1549593; (IGF1)	1-CC	2924/2970
	2-CA	1753/1771	1.01	0.93–1.09
	3-AA	323/259	1.27	1.07–1.50
4. rs6220; (IGF1)	1-AA	2643/2698
	2-AG	1933/1951	1.01	0.93–1.10
	3-GG	424/351	1.23	1.06–1.44
5. rs2946834; (IGF1)	1-CC	2295/2336
	2-CT	2171/2150	1.03	0.95–1.12
	3-TT	534/514	1.06	0.93–1.21
6. rs1568502; (IGF1R)	1-AA	2914/2955
	2-AG	1840/1807	1.03	0.95–1.12
	3-GG	246/238	1.05	0.87–1.26
7. IGF1R-10; (IGF1R)	1-AA	3169/3201
	2-Aa	1545/1582	0.99	0.91–1.08
	3-aa	286/217	1.33	1.11–1.60
8. rs2229765; (IGF1R)	1-GG	1523/1429
	2-GA	2533/2489	0.96	0.87–1.05
	3-AA	944/1082	0.82	0.73–0.92
9. rs8030950; (IGF1R)	1-CC	2737/2745
	2-CA	1902/1917	1.00	0.92–1.08
	3-AA	361/338	1.07	0.92–1.25
10. rs680; (IGF2)	1-GG	2538/2451
	2-GA	2074/2183	0.92	0.85–1.00
	3-AA	388/366	1.02	0.88–1.19
11. rs3741211; (IGF2)	1-TT	1936/1971
	2-TC	2367/2269	1.06	0.98–1.16
	3-CC	697/760	0.93	0.83–1.05
12. IGF2-05; (IGF2)	1-AA	2651/2694
	2-Aa	1955/1952	1.02	0.94–1.11
	3-aa	394/354	1.13	0.97–1.32
13. IGF2-06; (IGF2)	1-AA	2160/2162
	2-Aa	2237/2284	0.98	0.90–1.07
	3-aa	603/554	1.09	0.96–1.24
14. rs2132571; (IGFBP3)	1-GG	2415/2407
	2-GA	2163/2157	1.00	0.92–1.09
	3-AA	422/436	0.97	0.83–1.12
15. rs2471551; (IGFBP3)	1-GG	3225/3284
	2-GC	1591/1515	1.07	0.98–1.17
	3-CC	184/201	0.93	0.76–1.15
16. rs2854744; (IGFBP3)	1-AA	1538/1469
	2-AC	2487/2475	0.96	0.88–1.05
	3-CC	975/1056	0.88	0.79–0.99
17. rs2132572; (IGFBP3)	1-GG	2908/3027
	2-GA	1805/1728	1.09	1.00–1.18
	3-AA	287/245	1.22	1.02–1.46
18. rs3024496; (IL10)	1-TT	1218/1235
	2-TC	2533/2549	1.01	0.92–1.11
	3-CC	1249/1216	1.04	0.93–1.17
19. rs1800872; (IL10)	1-CC	3059/3017
	2-CA	1660/1722	0.95	0.87–1.03
	3-AA	281/261	1.06	0.89–1.27
20. rs1800890; (IL10)	1-TT	1703/1701
	2-TA	2455/2508	0.98	0.90–1.07
	3-AA	842/791	1.06	0.95–1.20
21. rs1554286; (IL10)	1-CC	3400/3446
	2-CT	1431/1410	1.03	0.94–1.12
	3-TT	169/144	1.19	0.95–1.49
22. rs1800470; (TGFB1)	1-TT	1850/1914
	2-TC	2372/2399	1.02	0.94–1.11
	3-CC	778/687	1.17	1.04–1.32
23. rs699947; (VEGF)	1-CC	1236/1273
	2-CA	2511/2463	1.05	0.95–1.16
	3-AA	1253/1264	1.02	0.91–1.14
24. rs1570360; (VEGF)	1-GG	2278/2341
	2-GA	2214/2132	1.07	0.98–1.16
	3-AA	508/527	0.99	0.87–1.13
25. rs2010963; (VEGF)	1-GG	2354/2279
	2-GC	2133/2157	0.96	0.88–1.04
	3-CC	513/564	0.88	0.77–1.01
26. rs3025039; (VEGF)	1-CC	3744/3741
	2-CT	1160/1174	0.99	0.90–1.08
	3-TT	96/85	1.13	0.84–1.52

aData collected from the literature [39].