Double-Bottom Chaotic Map Particle Swarm Optimization Based on Chi-Square Test to Determine Gene-Gene Interactions

Table 2

Estimation of the best risk model of gene-gene interaction on the occurrence of breast cancer as determined by PSO, CPSO, and DBMPSO.

	Combined; SNP	SNP; genotypes	Cases; number	Controls; number	𝜒^2 value	Odds; ratio	95% CI	𝑃 value
2-SNP
PSO	1,7	1-3	259	195	9.451	1.346	1.11–1.63	0.002
		Other	4741	4805
CPSO	1,7	1-3	259	195	9.451	1.346	1.11–1.63	0.002
		Other	4741	4805
DBMPSO	1,7	1-3	259	195	9.451	1.346	1.11–1.63	0.002
		Other	4741	4805
3-SNP
PSO	2,14,25	3-1-1	84	62	3.364	1.361	0.98–1.89	0.068
		Other	4916	4938
CPSO	1,6,7	1-1-3	148	116	3.997	1.285	1.00–1.64	0.046
		Other	4850	4884
DBMPSO	7,11,21	3-2-1	93	57	8.772	1.644	1.18–2.29	0.003
		Other	4907	4943
4-SNP
PSO	1,14,20,23	3-3-1-2	2	0	1.000	3.001	0.31–28.86	0.341
		Other	4998	5000
CPSO	1,4,11,14	1-3-2-1	86	67	2.396	1.289	0.93–1.78	0.123
		Other	4914	4933
DBMPSO	1,7,11,21	1-3-2-1	87	53	8.374	1.653	1.17–2.33	0.004
		Other	4913	4947
5-SNP
PSO	2,7,15,18,24	1-3-1-3-2	15	8	2.135	1.878	0.80–4.43	0.151
		Other	4985	4992
CPSO	3,10,17,24,26	3-1-1-3-1	9	3	3.004	3.004	0.81–11.10	0.099
		Other	4991	4997
DBMPSO	1,2,7,11,21	1-1-3-2-1	49	27	6.417	1.823	1.14–2.92	0.013
		Other	4951	4973
6-SNP
PSO	2,6,8,16,18,25	3-1-1-2-3-2	3	1	1.000	3.001	0.31–28.86	0.341
		Other	4997	4999
CPSO	2,11,16,18,22,23	1-2-1-2-3-2	14	9	1.089	1.557	0.67–3.60	0.301
		Other	4986	4991
DBMPSO	1,2,7,10,11,21	1-1-3-1-2-1	27	12	6.417	2.257	1.14–4.46	0.019
		Other	4973	4988
7-SNP
PSO	1,3,6,12,21,24,26	1-3-2-1-3-1-1	2	0	1.000	3.001	0.31–28.86	0.341
		Other	4998	5000
CPSO	1,2,3,9,19,21,24	1-1-3-1-1-2-3	4	1	1.801	4.002	0.45–35.82	0.215
		Other	4996	4999
DBMPSO	1,3,5,9,17,23,24	1-3-2-1-2-2-1	10	1	7.372	10.018	1.28–78.29	0.028
		Other	4990	4999