Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 172646, 7 pages
http://dx.doi.org/10.1155/2014/172646
Research Article

Role of 99mTc-ECD SPECT in the Management of Children with Craniosynostosis

1Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India
2Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar 751019, India
3Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
4Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India

Received 9 February 2014; Revised 31 March 2014; Accepted 31 March 2014; Published 16 April 2014

Academic Editor: Nader Pouratian

Copyright © 2014 Mayadhar Barik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose of the Report. There is a paucity of data on correlation of various imaging modalities with clinical findings in craniosynostosis. Moreover, no study has specifically reported the role of -ECD SPECT in a large number of subjects with craniosynostosis. Materials and Methods. We prospectively analyzed a cohort of 85 patients with craniosynostosis from year 2007 to 2012. All patients underwent evaluation with -ECD SPECT and the results were correlated with radiological and surgical findings. Results. -ECD SPECT revealed regional perfusion abnormalities in the cerebral hemisphere corresponding to the fused sutures preoperatively that disappeared postoperatively in all the cases. Corresponding to this, the mean mental performance quotient (MPQ) increased significantly postoperatively only in those children with absent perfusion defect postoperatively. Conclusions. Our study suggests that early surgery and release of craniosynostosis in patients with preoperative perfusion defects (absent on -ECD SPECT study) are beneficial, as theylead to improved MPQ after surgery.