Research Article
1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies
Table 3
Zone of inhibition of synthesized 1,3,4-oxadiazole derivatives against selected microbial strains.
| Compound | Concentration (µg/mL) | Zone of inhibition (mm) | E. coli | P. aeruginosa | S. aureus | S. epidermidis |
| 6a | 100 | | — | | | 200 | | — | | | 400 | | — | | |
| 6b | 100 | | — | | | 200 | | | | | 400 | | | | |
| 6c | 100 | | — | | — | 200 | | — | | | 400 | | — | | |
| 6d | 100 | | | | — | 200 | | | | | 400 | | | | |
| 6e | 100 | | | | | 200 | | | | | 400 | | | | |
| 6f | 100 | | | | | 200 | | | | | 400 | | | | |
| 6g | 100 | | — | | | 200 | | — | | | 400 | | — | | |
| 6h | 100 | | — | | | 200 | | | | | 400 | | | | |
| 13a | 50 | | | | | 100 | | | | | 200 | | | | |
| 13b | 50 | | | | | 100 | | | | | 200 | | | | |
| 13c | 50 | | | | | 100 | | | | | 200 | | | | |
| 13d | 50 | | | | | 100 | | | | | 200 | | | | |
| 13e | 50 | | | | | 100 | | | | | 200 | | | | |
| 13f | 50 | | | | | 100 | | | | | 200 | | | | |
| 13g | 50 | | | | | 100 | | | | | 200 | | | | |
| 13h | 50 | | | | | 100 | | | | | 200 | | | | |
| Amoxicillin | 200 | | — | | | 400 | | | | | 800 | | | | |
| Cefixime | 200 | | — | — | | 400 | | — | — | | 800 | | | | |
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Values are expressed as mean ± standard deviation of the three replicates. Diameter of the well is not included in zone of inhibition.
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