Research Article
1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies
Table 5
Observed and predicted antibacterial activity of synthesized 1,3,4-oxadiazole derivatives against Escherichia coli and Pseudomonas aeruginosa.
| | Compounds | Observed activity | Calculated activity | Residuals | Observed activity | Calculated activity | Residuals |
| | 6a | 1.39794 | 1.42696 | −0.02902 | 1.39794 | 1.380355 | 0.017585 | | 6b | 1.39794 | 1.49081 | −0.09287 | — | — | — | | 6c | | — | — | 1.69897 | 1.693166 | 0.005804 | | 6d | — | — | — | 1.69897 | 1.749717 | −0.05075 | | 6e | 1.09691 | 1.17324 | −0.07633 | — | — | — | | 6f | — | — | — | 1.69897 | 1.739458 | −0.04049 | | 6g | 1.39794 | 1.28492 | 0.113024 | 1.69897 | 1.565732 | 0.133238 | | 8a | 1.09691 | 1.10285 | −0.00594 | — | — | — | | 8b | 1.09691 | 1.22329 | −0.12638 | — | — | — | | 8c | 1.09691 | 1.01685 | 0.080062 | — | — | — | | 8d | 2 | 1.95106 | 0.048936 | 2 | 2.143298 | −0.1433 | | 8e | — | — | — | — | — | — | | 8f | 1.69897 | 1.66784 | 0.031132 | — | — | — | | 8g | 1.09691 | 1.0879 | 0.009007 | 1.39794 | 1.417768 | −0.01983 | | 13a | 1.09691 | 1.2223 | −0.12539 | 1.09691 | 1.241458 | −0.14455 | | 13b | 0.79588 | 0.9957 | −0.19982 | 1.69897 | 1.59415 | 0.10482 | | 13d | 1.09691 | 1.13534 | −0.03843 | 1.39794 | 1.422187 | −0.02425 | | 13e | 0.79588 | 0.80956 | −0.01368 | — | — | — | | 13f | 1.39794 | 1.03279 | 0.365149 | 1.69897 | 1.642724 | 0.056246 | | 13h | 1.09691 | 1.11426 | −0.01735 | 2 | 1.769982 | 0.230018 |
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(—) Compounds are not included in QSAR model development.
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