Research Article
1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies
Table 6
Observed and predicted antibacterial activities of 1,3,4-oxadiazole derivatives against Staphylococcus aureus and Staphylococcus epidermidis.
| | Compounds | Staphylococcus aureus | Staphylococcus epidermidis | | Observed activity | Calculated activity | Residuals | Observed activity | Calculated activity | Residuals |
| | 6a | 1.69897 | 1.747218 | −0.04825 | 2 | 2.018882 | −0.018880 | | 6b | 2 | 2.061071 | −0.06107 | 1.69897 | 1.726729 | −0.027760 | | 6c | 2 | 1.875044 | 0.124956 | 1.69897 | 1.573922 | 0.125048 | | 6d | 2 | 1.834783 | 0.165217 | — | — | — | | 6e | 1.69897 | 2.002453 | −0.30348 | 1.69897 | 1.740717 | −0.041750 | | 6f | 1.69897 | 1.827713 | −0.12874 | — | — | — | | 6g | 1.69897 | 1.462069 | 0.236901 | — | — | — | | 8a | — | — | — | — | — | — | | 8b | 1.09691 | 1.17198 | −0.07507 | 1.69897 | 1.591267 | 0.107703 | | 8c | 1.09691 | 1.151688 | −0.05478 | 1.69897 | 1.732577 | −0.033610 | | 8d | 2 | 1.808758 | 0.191242 | 1.39794 | 1.343779 | 0.054161 | | 8e | 2 | 1.885819 | 0.114181 | 1.09691 | 0.887520 | 0.209390 | | 8f | 1.69897 | 1.552991 | 0.145979 | 1.39794 | 1.353518 | 0.044422 | | 8g | 1.09691 | 1.268834 | −0.17192 | 1.39794 | 1.327929 | 0.070011 | | 13a | — | — | — | 1.39794 | 1.308439 | 0.089501 | | 13b | — | — | — | 0.79588 | 1.030457 | −0.23458 | | 13d | 1.09691 | 1.056386 | 0.040524 | 1.39794 | 1.425514 | −0.02757 | | 13e | — | — | — | 1.09691 | 1.227397 | −0.13049 | | 13f | 1.39794 | 1.647697 | −0.24976 | 1.09691 | 1.118010 | −0.02110 | | 13h | 1.69897 | 1.611633 | 0.087337 | 1.09691 | 1.165225 | −0.06832 |
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(—) Compounds are not included in QSAR model development.
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