Bortezomib Treatment Produces Nocifensive Behavior and Changes in the Expression of TRPV1, CGRP, and Substance P in the Rat DRG, Spinal Cord, and Sciatic Nerve
Figure 4
RT-PCR analysis of TRPV1 and CGRP mRNAs in DRG ((a), (c), (i), and (k)) and spinal cord ((e), (g), (m), and (o)) of acutely and chronically BTZ-treated rats. (b), (d), (f), (h), (j), (l), (n), and (p) Relative levels of TRPV1 and CGRP expression with densitometric analysis of the grey levels expressed as a percentage of the optical density (O.D.) ratio of the TRPV1- and CGRP-positive bands to the relevant GAPDH-positive ones. Ctrl: control rats. Error bars represent standard deviation. Letters “A” and “B” denote significant differences between relative mRNA levels in ctrl versus BTZ-treated rats ((b) ; (d) and (h) ).
