Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat

Table 3

Plasma parameters in rats contaminated to uranium in drinking water for 9 months.

Parameters	Noncontaminated	Uranium (mg/L)
		0.2	10	20	40	120
Glycaemia
Glucose (mM)	11.58 ± 1.14	11.1 ± 1.17	10.51 ± 1.36	11.74 ± 1.52	9.91 ± 0.95	10.63 ± 1.23
Lipids
Cholesterol (mM)	1.99 ± 0.54	2.3 ± 0.63	2.33 ± 0.38	2.14 ± 0.89	2.40 ± 0.82	2.43 ± 0.76
LDL-cholesterol (mM)	0.38 ± 0.51	0.46 ± 0.22	0.48 ± 0.13	0.41 ± 0.73	0.50 ± 0.35	0.36 ± 0.38
HDL-cholesterol (mM)	1.40 ± 0.41	1.59 ± 0.38	1.65 ± 0.32	1.54 ± 0.63	1.62 ± 0.51	1.58 ± 0.89
Phospholipids B (g/L)	1.38 ± 0.25	1.54 ± 0.28	1.56 ± 0.16	1.59 ± 0.44	1.64 ± 0.38	1.72 ± 0.44
Triglycerides (mM)	1.27 ± 0.47	1.60 ± 0.73	1.53 ± 0.47	2.0 ± 0.92	1.59 ± 0.57	1.74 ± 0.54
Liver integrity
ALAT (U/L)	43.4 ± 12.3	43.0 ± 16.1	37.6 ± 11.7	38.0 ± 10.75	37.8 ± 19.6	139.9 ± 183.0
ASAT (U/L)	118.1 ± 38.9	108.6 ± 35.4	93.1 ± 27.5	98.4 ± 26.9	96.1 ± 42.7	231.9 ± 225.0
Bilirubin (µM)	55.6 ± 4.74	60.7 ± 3.5	61.0 ± 7.6	63.2 ± 10.1	58.0 ± 4.4	60.9 ± 4.7
Renal function
Creatinine (µM)	49.3 ± 3.32	50.2 ± 4.11	50.4 ± 4.74	52.0 ± 4.74	47.0 ± 4.4	48.9 ± 5.1
Urea (mM)	5.27 ± 0.82	5.22 ± 0.82	5.47 ± 0.89	5.81 ± 1.04	4.81 ± 0.82	5.30 ± 0.95
Iron metabolism
Iron (µM)	31.5 ± 7.91	26.6 ± 3.16	33.4 ± 7.27	33.3 ± 5.7	27.6 ± 5.4	30.3 ± 8.5
Ferritin (ng/L)	31.1 ± 13.0	36.0 ± 21.5	39.3 ± 18.34	21.3 ± 11.4	20.3 ± 13.9	23.9 ± 18.3
Transferrin (g/L)	1.39 ± 0.13	1.49 ± 0.19	1.53 ± 0.16	1.55 ± 0.38	1.58 ± 0.22	1.60 ± 0.19
Ceruloplasmin (mg/L)	72.3 ± 8.5	70.2 ± 28.8	81.6 ± 13.6	63.5 ± 19.3	89.1 ± 17.4	90.4 ± 24.4
Red blood cells (×10^12/L)	9.04 ± 1.30	9.48 ± 1.9	9.28 ± 1.1	9.28 ± 2.0	9.74 ± 2.0	8.90 ± 4.6
Hematocrit (%)	43.9 ± 8.9	46.8 ± 14.2	46.4 ± 9.8	45.5 ± 8.2	47.8 ± 11.1	42.7 ± 20.6
Hemoglobin (g/L)	14.2 ± 2.21	14.7 ± 1.9	14.6 ± 2.53	14.7 ± 1.9	14.9 ± 1.9	13.8 ± 7.0

Mean ± SD, 𝑛=10 per group. There are no significant differences between groups (one-way ANOVA with 𝑃<0.05 significant).