Research Article
Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat
Table 6
Symopsis of uranium accumulation and effects in rats contaminated with uranium in drinking water for 9 months.
| | Uranium (mg/L) | 0.2 | 2 | 5 | 10 | 20 | 40 | 120 |
| | Health | . | | | | | | | | Body weight | = | = | = | = | = | = | = | | Water consumption | = | = | = | = | = | = | = | | Food consumption | = | = | = | = | = | = | = | | Intestine | | | | | | | | | Gene expression of cytokines | = | = | | | | = | | | Protein expression of cytokines | = | = | | | | = | | | Immune cell number | = | = | | | = | = | = | | Histology | = | = | | = | = | = | = | | Kidney | | | | | | | | | Uranium accumulation | | | | | | | | | Gene expression of EMX | | | | | | | | | Protein expression of EMX | | | | = | | = | = | | Histology | = | = | = | = | = | = | = | | Plasma parameters | = | = | = | = | = | = | = | | Liver | | | | | | | | | Uranium accumulation | = | = | = | = | | | | | Gene expression EMX | | | | | | | = | | Protein expression EMX | | = | | = | = | = | | | Enzyme activity EMX | | | | = | = | = | | | Gene expression Chol Met | = | | | | = | = | | | Enzyme activity Chol Met | | | | | = | | | | Histology | = | = | = | = | = | | | | Plasma parameters | = | | | = | = | = | = | | Haematopoiesis | | | | | | | | | Uranium accumulation in bone | | = | | | | | | | Bone marrow progenitors | = | | | | = | | = | | Spleen progenitors | = | | | | = | | = | | Blood cell counts | = | | | = | = | = | = | | Plasma cytokines | = | | = | | = | = | = | | Brain | | | | | | | | | Uranium accumulation | | = | | = | | = | = | | Antioxidant enzymes | | | | | | | | | Cholinergic pathway | = | = | | | | = | = |
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EMX: enzymes and transcription factors of xenobiotic metabolism; Chol Met: enzymes and transcription factors of cholesterol metabolism.
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