Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity
Table 2
Effects of Ashwagandha water extract on lead induced oxidative damage to CAT, SOD, GSH, and LPx in rat brain regions, liver, and kidney.
Groups
Kidney
Liver
Hippocampus
Hypothalamus
Cortex
Catalase (CAT)—units/minute/g
C
10.05 ± 1.37
3.72 ± 1.20
18.80 ± 1.95
11.47 ± 0.47
10.24 ± 1.52
LN
3.80 ± 1.68*
4.95 ± 1.68*
10.57 ± 1.83*
4.58 ± 0.84*
5.35 ± 1.20*
LN + AS
12.37 ± 4.26#
7.00 ± 1.71*#
9.56 ± 1.07*
9.31 ± 1.17#
11.37 ± 1.95#
Cu–Zn (SOD)—units/mg
C
13.44 ± 2.83
10.89 ± 2.64
21.25 ± 4.55
19.88 ± 3.58
13.60 ± 4.61
LN
9.21 ± 1.59
6.74 ± 1.31*
12.37 ± 1.88*
11.52 ± 1.03*
8.66 ± 2.09*
LN + AS
13.03 ± 0.09#
7.26 ± 1.43
12.07 ± 2.51*
22.13 ± 3.03#
9.86 ± 2.54*
Glutathione (GSH)—units/minute/g
C
3.34 ± 0.09
4.11 ± 0.13
3.48 ± 0.09
3.71 ± 0.11
3.22 ± 0.39
LN
3.28 ± 0.07
3.69 ± 0.16
3.29 ± 0.05
3.16 ± 0.12
3.45 ± 0.21
LN + AS
3.56 ± 0.09
3.92 ± 0.13
3.59 ± 0.05
3.54 ± 0.11
3.89 ± 0.31
Lipid peroxidation (LPx)—nmoles MDA/mL
C
10.43 ± 2.31
20.07 ± 1.87
4.78 ± 0.23
5.29 ± 0.22
10.76 ± 0.53
LN
23.66 ± 1.75*
22.30 ± 0.53*
13.75 ± 1.71*
12.05 ± 1.03*
18.97 ± 1.65*
LN + AS
11.42 ± 0.83#
14.61 ± 0.67#
09.82 ± 1.04*#
06.39 ± 0.67#
14.61 ± 0.82*#
Data are expressed as mean ± SEM. was considered significant. *represents significant difference compared to control group. #represents significant difference compared to lead treated animals (LN group).
