BioMed Research International / 2014 / Article / Tab 2

Research Article

Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity

Table 2

Effects of Ashwagandha water extract on lead induced oxidative damage to CAT, SOD, GSH, and LPx in rat brain regions, liver, and kidney.

GroupsKidneyLiverHippocampusHypothalamusCortex

Catalase (CAT)—units/minute/g
C10.05 ± 1.373.72 ± 1.2018.80 ± 1.9511.47 ± 0.4710.24 ± 1.52
LN3.80 ± 1.68*4.95 ± 1.68* 10.57 ± 1.83*4.58 ± 0.84*5.35 ± 1.20*
LN + AS12.37 ± 4.26#7.00 ± 1.71*#9.56 ± 1.07*9.31 ± 1.17#11.37 ± 1.95#

Cu–Zn (SOD)—units/mg
C13.44 ± 2.8310.89 ± 2.6421.25 ± 4.5519.88 ± 3.5813.60 ± 4.61
LN9.21 ± 1.596.74 ± 1.31*12.37 ± 1.88*11.52 ± 1.03*8.66 ± 2.09*
LN + AS13.03 ± 0.09#7.26 ± 1.4312.07 ± 2.51*22.13 ± 3.03#9.86 ± 2.54*

Glutathione (GSH)—units/minute/g
C3.34 ± 0.094.11 ± 0.133.48 ± 0.093.71 ± 0.113.22 ± 0.39
LN3.28 ± 0.073.69 ± 0.163.29 ± 0.053.16 ± 0.123.45 ± 0.21
LN + AS3.56 ± 0.093.92 ± 0.133.59 ± 0.053.54 ± 0.113.89 ± 0.31

Lipid peroxidation (LPx)—nmoles MDA/mL
C10.43 ± 2.3120.07 ± 1.874.78 ± 0.235.29 ± 0.2210.76 ± 0.53
LN23.66 ± 1.75*22.30 ± 0.53*13.75 ± 1.71*12.05 ± 1.03*18.97 ± 1.65*
LN + AS11.42 ± 0.83#14.61 ± 0.67#09.82 ± 1.04*#06.39 ± 0.67#14.61 ± 0.82*#

Data are expressed as mean ± SEM. was considered significant. *represents significant difference compared to control group. #represents significant difference compared to lead treated animals (LN group).

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