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BioMed Research International
Volume 2014, Article ID 182303, 14 pages
http://dx.doi.org/10.1155/2014/182303
Review Article

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

1Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung District, Kaohsiung 833, Taiwan
2Department of Biological Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
3Department of Emergency Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung District, Kaohsiung 833, Taiwan
4Department of Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung District, Kaohsiung 833, Taiwan
5Department of Radiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung District, Kaohsiung 833, Taiwan

Received 25 February 2014; Accepted 27 March 2014; Published 14 May 2014

Academic Editor: Hung-Chen Wang

Copyright © 2014 Ya-Ting Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. W. Weiner, D. P. Veitch, P. S. Aisen et al., “The Alzheimer's disease neuroimaging initiative: a review of papers published since its inception,” Alzheimer's and Dementia, vol. 8, no. 1, supplement, pp. S1–S68, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. J. A. Hardy and G. A. Higgins, “Alzheimer's disease: the amyloid cascade hypothesis,” Science, vol. 256, no. 5054, pp. 184–185, 1992. View at Google Scholar · View at Scopus
  3. M. A. Smith, C. A. Rottkamp, A. Nunomura, A. K. Raina, and G. Perry, “Oxidative stress in Alzheimer's disease,” Biochimica et Biophysica Acta, vol. 1502, no. 1, pp. 139–144, 2000. View at Google Scholar
  4. L. Migliore, I. Fontana, F. Trippi et al., “Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients,” Neurobiology of Aging, vol. 26, no. 5, pp. 567–573, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. Á. Casado, M. Encarnación López-Fernández, M. Concepción Casado, and R. De La Torre, “Lipid peroxidation and antioxidant enzyme activities in vascular and alzheimer dementias,” Neurochemical Research, vol. 33, no. 3, pp. 450–458, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. J. A. Serra, R. O. Domínguez, E. S. De Lustig et al., “Parkinson's disease is associated with oxidative stress: comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients,” Journal of Neural Transmission, vol. 108, no. 10, pp. 1135–1148, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. D. O. Cristalli, N. Arnal, F. A. Marra, M. J. T. De Alaniz, and C. A. Marra, “Peripheral markers in neurodegenerative patients and their first-degree relatives,” Journal of the Neurological Sciences, vol. 314, no. 1-2, pp. 48–56, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Carantoni, G. Zuliani, M. R. Munari, K. D'Elia, E. Palmieri, and R. Fellin, “Alzheimer disease and vascular dementia: relationships with fasting glucose and insulin levels,” Dementia and Geriatric Cognitive Disorders, vol. 11, no. 3, pp. 176–180, 2000. View at Google Scholar · View at Scopus
  9. A. J. Sinclair, A. J. Bayer, J. Johnston, C. Warner, and S. R. Maxwell, “Altered plasma antioxidant status in subjects with Alzheimer's disease and vascular dementia,” International Journal of Geriatric Psychiatry, vol. 13, no. 12, pp. 840–845, 1998. View at Google Scholar
  10. C. J. Foy, A. P. Passmore, M. D. Vahidassr, I. S. Young, and J. T. Lawson, “Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease,” QJM, vol. 92, no. 1, pp. 39–45, 1999. View at Google Scholar · View at Scopus
  11. Y. Ihara, T. Hayabara, K. Sasaki et al., “Free radicals and superoxide dismutase in blood of patients with Alzheimer's disease and vascular dementia,” Journal of the Neurological Sciences, vol. 153, no. 1, pp. 76–81, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. I. Guidi, D. Galimberti, S. Lonati et al., “Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease,” Neurobiology of Aging, vol. 27, no. 2, pp. 262–269, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Bermejo, P. Gomez-Serranillos, J. Santos, E. Pastor, P. Gil, and S. Martin-Aragon, “Determination of malonaldehyde in Alzheimer's disease: a comparative study of high-performance liquid chromatography and thiobarbituric acid test,” Gerontology, vol. 43, no. 4, pp. 218–222, 1997. View at Google Scholar · View at Scopus
  14. M. Y. Aksenov, M. V. Aksenova, D. A. Butterfield, J. W. Geddes, and W. R. Markesbery, “Protein oxidation in the brain in Alzheimer's disease,” Neuroscience, vol. 103, no. 2, pp. 373–383, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. I. Bourdel-Marchasson, M.-C. Delmas-Beauviex, E. Peuchant et al., “Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients,” Age and Ageing, vol. 30, no. 3, pp. 235–241, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Mecocci, M. Cristina Polidori, A. Cherubini et al., “Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease,” Archives of Neurology, vol. 59, no. 5, pp. 794–798, 2002. View at Google Scholar · View at Scopus
  17. S. Aldred, S. Bennett, and P. Mecocci, “Increased low-density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease,” Clinical Biochemistry, vol. 43, no. 3, pp. 267–271, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. A. Korolainen and T. Pirttilä, “Cerebrospinal fluid, serum and plasma protein oxidation in Alzheimer's disease,” Acta Neurologica Scandinavica, vol. 119, no. 1, pp. 32–38, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Castegna, V. Thongboonkerd, J. B. Klein, B. Lynn, W. R. Markesberyl, and D. A. Butterfield, “Proteomic identification of nitrated proteins in Alzheimer's disease brain,” Journal of Neurochemistry, vol. 85, no. 6, pp. 1394–1401, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Aybek, F. Ercan, D. Aslan, and T. Şahiner, “Determination of malondialdehyde, reduced glutathione levels and APOE4 allele frequency in late-onset Alzheimer's disease in Denizli, Turkey,” Clinical Biochemistry, vol. 40, no. 3-4, pp. 172–176, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Ozcankaya and N. Delibas, “Malondialdehyde, superoxide dismutase, melatonin, iron, copper, and zinc blood concentrations in patients with Alzheimer disease: cross-sectional study,” Croatian Medical Journal, vol. 43, no. 1, pp. 28–32, 2002. View at Google Scholar · View at Scopus
  22. J. A. Serra, R. O. Domínguez, E. R. Marschoff, E. M. Guareschi, A. L. Famulari, and A. Boveris, “Systemic oxidative stress associated with the neurological diseases of aging,” Neurochemical Research, vol. 34, no. 12, pp. 2122–2132, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Sinem, K. Dildar, E. Gökhan, B. Melda, Y. Orhan, and M. Filiz, “The serum protein and lipid oxidation marker levels in Alzheimer's disease and effects of cholinesterase inhibitors and antipsychotic drugs therapy,” Current Alzheimer Research, vol. 7, no. 5, pp. 463–469, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. L. L. Torres, N. B. Quaglio, G. T. De Souza et al., “Peripheral oxidative stress biomarkers in mild cognitive impairment and Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 26, no. 1, pp. 59–68, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. M. C. Polidori and P. Mecocci, “Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease,” Journal of Alzheimer's Disease, vol. 4, no. 6, pp. 517–522, 2002. View at Google Scholar · View at Scopus
  26. M. Padurariu, A. Ciobica, L. Hritcu, B. Stoica, W. Bild, and C. Stefanescu, “Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease,” Neuroscience Letters, vol. 469, no. 1, pp. 6–10, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Martín-Aragón, P. Bermejo-Bescós, J. Benedí et al., “Metalloproteinase's activity and oxidative stress in mild cognitive impairment and Alzheimer's disease,” Neurochemical Research, vol. 34, no. 2, pp. 373–378, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. M. C. Puertas, J. M. Martínez-Martos, M. P. Cobo, M. P. Carrera, M. D. Mayas, and M. J. Rami'rez-Expósito, “Plasma oxidative stress parameters in men and women with early stage Alzheimer type dementia,” Experimental Gerontology, vol. 47, no. 8, pp. 625–630, 2012. View at Google Scholar
  29. M. A. Fernandes, M. T. Proenca, A. J. Nogueira et al., “Influence of apolipoprotein E genotype on blood redox status of Alzheimer's disease patients,” International Journal of Molecular Medicine, vol. 4, no. 2, pp. 179–186, 1999. View at Google Scholar · View at Scopus
  30. C. Galbusera, M. Facheris, F. Magni et al., “Increased susceptibility to plasma lipid peroxidation in Alzheimer disease patients,” Current Alzheimer Research, vol. 1, no. 2, pp. 103–109, 2004. View at Google Scholar · View at Scopus
  31. I. Ceballos-Picot, M. Merad-Boudia, A. Nicole et al., “Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer's type—place of the extracellular glutathione peroxidase,” Free Radical Biology and Medicine, vol. 20, no. 4, pp. 579–587, 1996. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Gironi, A. Bianchi, A. Russo et al., “Oxidative imbalance in different neurodegenerative diseases with memory impairment,” Neurodegenerative Diseases, vol. 8, no. 3, pp. 129–137, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Kalman, I. Dey, S. V. Ilona et al., “Platelet membrane fluidity and plasma malondialdehyde levels in Alzheimer's demented patients with and without family history of dementia,” Biological Psychiatry, vol. 35, no. 3, pp. 190–194, 1994. View at Publisher · View at Google Scholar · View at Scopus
  34. L. T. McGrath, B. M. McGleenon, S. Brennan, D. McColl, S. McIlroy, and A. P. Passmore, “Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde,” QJM, vol. 94, no. 9, pp. 485–490, 2001. View at Google Scholar · View at Scopus
  35. M. A. Sekler, J. M. Jiménez, L. Rojo et al., “Cognitive impairment and Alzheimer's disease: links with oxidative stress and cholesterol metabolism,” Neuropsychiatric Disease and Treatment, vol. 4, no. 4, pp. 715–722, 2008. View at Google Scholar · View at Scopus
  36. C. Jeandel, M. B. Nicolas, F. Dubois, F. Nabet-Belleville, F. Penin, and G. Cuny, “Lipid peroxidation and free radical scavengers in Alzheimer's disease,” Gerontology, vol. 35, no. 5-6, pp. 275–282, 1989. View at Google Scholar · View at Scopus
  37. M. Schrag, C. Mueller, M. Zabel et al., “Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: a meta-analysis,” Neurobiology of Disease, vol. 59, pp. 100–110, 2013. View at Google Scholar
  38. M. Uno, K. T. Kitazato, K. Nishi, H. Itabe, and S. Nagahiro, “Raised plasma oxidised LDL in acute cerebral infarction,” Journal of Neurology Neurosurgery and Psychiatry, vol. 74, no. 3, pp. 312–316, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. C. E. Teunissen, J. De Vente, H. W. M. Steinbusch, and C. De Bruijn, “Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid,” Neurobiology of Aging, vol. 23, no. 4, pp. 485–508, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. Z.-Y. Cai, Y. Yan, L. Yan et al., “Serum level of MMP-2, MMP-9 and Ox-LDL in Alzheimer's disease with hyperlipoidemia,” Journal of Medical Colleges of PLA, vol. 22, no. 6, pp. 352–356, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Bermejo, S. Martín-Aragón, J. Benedí et al., “Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment,” Free Radical Research, vol. 42, no. 2, pp. 162–170, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. C. C. Conrad, P. L. Marshall, J. M. Talent, C. A. Malakowsky, J. Choi, and R. W. Gracy, “Oxidized proteins in Alzheimer's plasma,” Biochemical and Biophysical Research Communications, vol. 275, no. 2, pp. 678–681, 2000. View at Google Scholar
  43. R. Sultana, H. F. Poon, J. Cai et al., “Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach,” Neurobiology of Disease, vol. 22, no. 1, pp. 76–87, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Choi, C. A. Malakowsky, J. M. Talent, C. C. Conrad, and R. W. Gracy, “Identification of oxidized plasma proteins in Alzheimer's disease,” Biochemical and Biophysical Research Communications, vol. 293, no. 5, pp. 1566–1570, 2002. View at Google Scholar
  45. M. A. Korolainen, T. A. Nyman, P. Nyyssönen, E. S. Hartikainen, and T. Pirttilä, “Multiplexed proteomic analysis of oxidation and concentrations of cerebrospinal fluid proteins in Alzheimer disease,” Clinical Chemistry, vol. 53, no. 4, pp. 657–665, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. N. Ahmed, U. Ahmed, P. J. Thornalley, K. Hager, G. Fleischer, and G. Münch, “Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment,” Journal of Neurochemistry, vol. 92, no. 2, pp. 255–263, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. A. Castegna, M. Aksenov, M. Aksenova et al., “Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1,” Free Radical Biology and Medicine, vol. 33, no. 4, pp. 562–571, 2002. View at Publisher · View at Google Scholar · View at Scopus
  48. H. Tohgi, T. Abe, K. Yamazaki, T. Murata, E. Ishizaki, and C. Isobe, “Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease,” Neuroscience Letters, vol. 269, no. 1, pp. 52–54, 1999. View at Publisher · View at Google Scholar · View at Scopus
  49. K. Hensley, M. L. Maidt, Z. Yu, H. Sang, W. R. Markesbery, and R. A. Floyd, “Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation,” Journal of Neuroscience, vol. 18, no. 20, pp. 8126–8132, 1998. View at Google Scholar · View at Scopus
  50. H. Ryberg, A.-S. Söderling, P. Davidsson, K. Blennow, K. Caidahl, and L. I. Persson, “Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease,” Neurochemistry International, vol. 45, no. 1, pp. 57–62, 2004. View at Publisher · View at Google Scholar · View at Scopus
  51. M. C. Polidori, W. Stahl, O. Eichler, I. Niestroj, and H. Sies, “Profiles of antioxidants in human plasma,” Free Radical Biology and Medicine, vol. 30, no. 5, pp. 456–462, 2001. View at Publisher · View at Google Scholar · View at Scopus
  52. T.-S. Kim, C.-U. Pae, S.-J. Yoon et al., “Decreased plasma antioxidants in patients with Alzheimer's disease,” International Journal of Geriatric Psychiatry, vol. 21, no. 4, pp. 344–348, 2006. View at Publisher · View at Google Scholar · View at Scopus
  53. J. K. Maesaka, G. Wolf-Klein, J. M. Piccione, and C. M. Ma, “Hypouricemia, abnormal renal tubular urate transport, and plasma natriuretic factor(s) in patients with Alzheimer's disease,” Journal of the American Geriatrics Society, vol. 41, no. 5, pp. 501–506, 1993. View at Google Scholar · View at Scopus
  54. P. Rinaldi, M. C. Polidori, A. Metastasio et al., “Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease,” Neurobiology of Aging, vol. 24, no. 7, pp. 915–919, 2003. View at Publisher · View at Google Scholar · View at Scopus
  55. C. Ruggiero, A. Cherubini, F. Lauretani et al., “Uric acid and dementia in community-dwelling older persons,” Dementia and Geriatric Cognitive Disorders, vol. 27, no. 4, pp. 382–389, 2009. View at Publisher · View at Google Scholar · View at Scopus
  56. D. J. Schretlen, A. B. Inscore, H. A. Jinnah, V. Rao, B. Gordon, and G. D. Pearlson, “Serum uric acid and cognitive function in community-dwelling older adults,” Neuropsychology, vol. 21, no. 1, pp. 136–140, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. L. Iuliano, R. Monticolo, G. Straface et al., “Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 21, no. 4, pp. 1383–1392, 2010. View at Publisher · View at Google Scholar · View at Scopus
  58. F. J. Jiménez-Jiménez, F. de Bustos, J. A. Molina et al., “Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease,” Journal of Neural Transmission, vol. 104, no. 6-7, pp. 703–710, 1997. View at Google Scholar
  59. Z. Zaman, S. Roche, P. Fielden, P. G. Frost, D. C. Niriella, and A. C. D. Cayley, “Plasma concentrations of vitamins A and E and carotenoids in Alzheimer's disease,” Age and Ageing, vol. 21, no. 2, pp. 91–94, 1992. View at Google Scholar · View at Scopus
  60. M. Glasø, G. Nordbø, L. Diep, and T. Bøhmer, “Reduced concentrations of several vitamins in normal weight patients with late-onset dementia of the Alzheimer type without vascular disease,” Journal of Nutrition, Health and Aging, vol. 8, no. 5, pp. 407–413, 2004. View at Google Scholar · View at Scopus
  61. M. Sano, C. Ernesto, R. G. Thomas et al., “A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease,” The New England Journal of Medicine, vol. 336, no. 17, pp. 1216–1222, 1997. View at Publisher · View at Google Scholar · View at Scopus
  62. S. Riviere, I. Birlouez-Aragon, F. Nourhashémi, and B. Vellas, “Low plasma vitamin C in Alzheimer patients despite an adequate diet,” International Journal of Geriatric Psychiatry, vol. 13, no. 11, pp. 749–754, 1998. View at Google Scholar
  63. C. A. von Arnim, F. Herbolsheimer, T. Nikolaus et al., “Dietary antioxidants and dementia in a population-based case-control study among older people in South Germany,” Journal of Alzheimer's Disease, vol. 31, no. 4, pp. 717–724, 2012. View at Google Scholar
  64. S. Schippling, A. Kontush, S. Arlt et al., “Increased lipoprotein oxidation in Alzheimer's disease,” Free Radical Biology and Medicine, vol. 28, no. 3, pp. 351–360, 2000. View at Publisher · View at Google Scholar · View at Scopus
  65. A. Cherubini, C. Ruggiero, M. C. Polidori, and P. Mecocci, “Potential markers of oxidative stress in stroke,” Free Radical Biology and Medicine, vol. 39, no. 7, pp. 841–852, 2005. View at Publisher · View at Google Scholar · View at Scopus
  66. N. Tabet, D. Mantle, Z. Walker, and M. Orrell, “Vitamins, trace elements, and antioxidant status in dementia disorders,” International Psychogeriatrics, vol. 13, no. 3, pp. 265–275, 2001. View at Publisher · View at Google Scholar · View at Scopus
  67. J. Snaedal, J. Kristinsson, S. Gunnarsdóttir, Á. Ólafsdóttir, M. Baldvinsson, and T. Jóhannesson, “Copper, ceruloplasmin and superoxide dismutase in patients with Alzheimer's disease. A case-control study,” Dementia and Geriatric Cognitive Disorders, vol. 9, no. 5, pp. 239–242, 1998. View at Publisher · View at Google Scholar · View at Scopus
  68. H. Kharrazi, A. Vaisi-Raygani, Z. Rahimi, H. Tavilani, M. Aminian, and T. Pourmotabbed, “Association between enzymatic and non-enzymatic antioxidant defense mechanism with apolipoprotein E genotypes in Alzheimer disease,” Clinical Biochemistry, vol. 41, no. 12, pp. 932–936, 2008. View at Publisher · View at Google Scholar · View at Scopus
  69. R. Perrin, S. Briancon, C. Jeandel et al., “Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer's disease: a case-control study,” Gerontology, vol. 36, no. 5-6, pp. 306–313, 1990. View at Google Scholar · View at Scopus
  70. L. Rossi, R. Squitti, P. Pasqualetti et al., “Red blood cell copper, zinc superoxide dismutase activity is higher in Alzheimer's disease and is decreased by D-penicillamine,” Neuroscience Letters, vol. 329, no. 2, pp. 137–140, 2002. View at Publisher · View at Google Scholar · View at Scopus
  71. M. E. De Leo, S. Borrello, M. Passantino et al., “Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer's disease,” Neuroscience Letters, vol. 250, no. 3, pp. 173–176, 1998. View at Publisher · View at Google Scholar · View at Scopus
  72. M. P. Bowes, J. A. Zivin, G. R. Thomas, H. Thibodeaux, and S. C. Fagan, “Acute hypertension, but not thrombolysis, increases the incidence and severity of hemorrhagic transformation following experimental stroke in rabbits,” Experimental Neurology, vol. 141, no. 1, pp. 40–46, 1996. View at Publisher · View at Google Scholar · View at Scopus
  73. I. Baldeiras, I. Santana, M. T. Proença et al., “Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 15, no. 1, pp. 117–128, 2008. View at Google Scholar · View at Scopus
  74. A. Nunomura, T. Tamaoki, N. Motohashi et al., “The earliest stage of cognitive impairment in transition from normal aging to alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons,” Journal of Neuropathology and Experimental Neurology, vol. 71, no. 3, pp. 233–241, 2012. View at Publisher · View at Google Scholar · View at Scopus
  75. G. P. Paraskevas, E. Kapaki, G. Libitaki, C. Zournas, I. Segditsa, and C. Papageorgiou, “Ascorbate in healthy subjects, amyotrophic lateral sclerosis and Alzheimer's disease,” Acta Neurologica Scandinavica, vol. 96, no. 2, pp. 88–90, 1997. View at Google Scholar · View at Scopus
  76. H. Vural, H. Demirin, Y. Kara, I. Eren, and N. Delibas, “Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer’s disease,” Journal of Trace Elements in Medicine & Biology, vol. 24, no. 3, pp. 169–173, 2010. View at Google Scholar