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BioMed Research International
Volume 2014, Article ID 182846, 7 pages
http://dx.doi.org/10.1155/2014/182846
Research Article

Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents

1Department of Food Science, National Pingtung University of Science and Technology, Neipu, Pingtung 91201, Taiwan
2College of Medicine and Life Science, Chung Hwa University of Medical Technology, Rende District, Tainan City 71703, Taiwan
3Department of Radiation Oncology, Taipei Medical University-Shuang Ho Hospital, and College of Medicine, Taipei Medical University, Taipei City 10361, Taiwan
4Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City 70101, Taiwan
5Department of Obs/Gyn, Tainan Sin-Lau Hospital, The Presbyterian Church in Taiwan, Tainan City 70142, Taiwan
6Department of Chinese Medicine, Tainan Sin-Lau Hospital, The Presbyterian Church in Taiwan, Tainan City 70142, Taiwan

Received 16 February 2014; Accepted 9 March 2014; Published 3 April 2014

Academic Editor: Juei-Tang Cheng

Copyright © 2014 Mei-Fen Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. L. Cohen and R. R. Townsend, “Update on pathophysiology and treatment of hypertension in the elderly,” Current Hypertension Reports, vol. 13, no. 5, pp. 330–337, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Regunathan, C. Youngson, W. Raasch, H. Wang, and D. J. Reis, “Imidazoline receptors and agmatine in blood vessels: a novel system inhibiting vascular smooth muscle proliferation,” The Journal of Pharmacology and Experimental Therapeutics, vol. 276, no. 3, pp. 1272–1282, 1996. View at Google Scholar · View at Scopus
  3. J. Yang, W.-Z. Wang, F.-M. Shen, and D.-F. Su, “Cardiovascular effects of agmatine within the rostral ventrolateral medulla are similar to those of clonidine in anesthetized rats,” Experimental Brain Research, vol. 160, no. 4, pp. 467–472, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Ernsberger, M. E. Graves, L. M. Graff et al., “I1-imidazoline receptors. Definition, characterization, distribution, and transmembrane signaling,” Annals of the New York Academy of Sciences, vol. 763, pp. 22–42, 1995. View at Publisher · View at Google Scholar · View at Scopus
  5. N. G. Morgan, S. L. Chan, M. Mourtada, L. K. Monks, and C. A. Ramsden, “Imidazolines and pancreatic hormone secretion,” Annals of the New York Academy of Sciences, vol. 881, pp. 217–228, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. T.-N. Lui, C.-W. Tsao, S.-Y. Huang, C.-H. Chang, and J.-T. Cheng, “Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells,” Neuroscience Letters, vol. 474, no. 3, pp. 144–147, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. C.-H. Chang, H.-T. Wu, K.-C. Cheng, H.-J. Lin, and J.-T. Cheng, “Increase of β-endorphin secretion by agmatine is induced by activation of imidazoline I2A receptors in adrenal gland of rats,” Neuroscience Letters, vol. 468, no. 3, pp. 297–299, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. P. A. van Zwieten and S. L. Peters, “Central I1-imidazoline receptors as targets of centrally acting antihypertensive drugs. Clinical pharmacology of moxonidine and rilmenidine,” Annals of the New York Academy of Sciences, vol. 881, pp. 420–429, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Esler, “High blood pressure management: potential benefits of I1 agents,” Journal of Hypertension, vol. 16, no. 3, pp. S19–S24, 1998. View at Google Scholar · View at Scopus
  10. G.-Y. Mar, M.-T. Chou, H.-H. Chung, N.-H. Chiu, M.-F. Chen, and J.-T. Cheng, “Changes of imidazoline receptors in spontaneously hypertensive rats,” International Journal of Experimental Pathology, vol. 94, no. 1, pp. 17–24, 2013. View at Publisher · View at Google Scholar
  11. C. Dardonville and I. Rozas, “Imidazoline binding sites and their ligands: an overview of the different chemical structures,” Medicinal Research Reviews, vol. 24, no. 5, pp. 639–661, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. F. L. Wynne, J. A. Payne, A. E. Cain, J. F. Reckelhoff, and R. A. Khalil, “Age-related reduction in estrogen receptor-mediated mechanisms of vascular relaxation in female spontaneously hypertensive rats,” Hypertension, vol. 43, no. 2, pp. 405–412, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. W. Raasch, U. Schäfer, F. Qadri, and P. Dominiak, “Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction,” British Journal of Pharmacology, vol. 135, no. 3, pp. 663–672, 2002. View at Google Scholar · View at Scopus
  14. F. Messerli, “Moxonidine: a new and versatile antihypertensive,” Journal of Cardiovascular Pharmacology, vol. 35, no. 4, pp. S53–S56, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. E. B. Monroy-Ordoñez, C. M. Villalón, L. E. Cobos-Puc, J. A. Márquez-Conde, A. Sánchez-López, and D. Centurión, “Evidence that some imidazoline derivatives inhibit peripherally the vasopressor sympathetic outflow in pithed rats,” Autonomic Neuroscience: Basic & Clinical, vol. 143, no. 1, pp. 40–45, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. R. A. Khalil, “Modulators of the vascular endothelin receptor in blood pressure regulation and hypertension,” Current Molecular Pharmacology, vol. 4, no. 3, pp. 176–186, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. G. V. Guinea, J. M. Atienza, F. J. Rojo et al., “Factors influencing the mechanical behaviour of healthy human descending thoracic aorta,” Physiological Measurement, vol. 31, no. 12, pp. 1553–1565, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. T. M. Cocks, P. J. Little, J. A. Angus, and E. J. Cragoe Jr., “Amiloride analogues cause endothelium-dependent relaxation in the canine coronary artery in vitro: possible role of Na+/Ca2+ exchange,” British Journal of Pharmacology, vol. 95, no. 1, pp. 67–76, 1988. View at Google Scholar · View at Scopus
  19. J. Y. Sung and H. C. Choi, “Metformin-induced AMP-activated protein kinase activation regulates phenylephrine-mediated contraction of rat aorta,” Biochemical and Biophysical Research Communications, vol. 421, no. 3, pp. 599–604, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. M.-F. Chen, J.-T. Tsai, L.-J. Chen et al., “Antihypertensive action of allantoin in animals,” BioMed Research International, vol. 2014, Article ID 690135, 6 pages, 2014. View at Publisher · View at Google Scholar
  21. S. Diamant, T. Eldar-Geva, and D. Atlas, “Imidazoline binding sites in human placenta: evidence for heterogeneity and a search for physiological function,” British Journal of Pharmacology, vol. 106, no. 1, pp. 101–108, 1992. View at Google Scholar · View at Scopus
  22. T. Miura, Y. Liu, M. Goto et al., “Mitochondrial ATP-sensitive K+ channels play a role in cardioprotection by Na+–H+ exchange inhibition against ischemia/reperfusion injury,” Journal of the American College of Cardiology, vol. 37, no. 3, pp. 957–963, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. W. I. Rosenblum, E. P. Wei, and H. A. Kontos, “Vasodilation of brain surface arterioles by blockade of Na–H+ antiport and its inhibition by inhibitors of KATP channel openers,” Brain Research, vol. 1005, no. 1-2, pp. 77–83, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. E. A. Ko, J. Han, I. D. Jung, and W. S. Park, “Physiological roles of K+ channels in vascular smooth muscle cells,” Journal of Smooth Muscle Research, vol. 44, no. 2, pp. 65–81, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. J. E. Brayden, “Functional roles of KATP channels in vascular smooth muscle,” Clinical and Experimental Pharmacology and Physiology, vol. 29, no. 4, pp. 312–316, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. N. Nakhostine and D. Lamontagne, “Adenosine contributes to hypoxia-induced vasodilation through ATP- sensitive K+ channel activation,” American Journal of Physiology: Heart and Circulatory Physiology, vol. 265, no. 4, pp. H1289–H1293, 1993. View at Google Scholar · View at Scopus
  27. M. Ghosh, S. T. Hanna, R. Wang, and J. R. McNeill, “Altered vascular reactivity and KATP channel currents in vascular smooth muscle cells from deoxycorticosterone acetate (DOCA)-salt hypertensive rats,” Journal of Cardiovascular Pharmacology, vol. 44, no. 5, pp. 525–531, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. C.-C. Tsai, T.-Y. Lai, W.-C. Huang, I.-M. Liu, and J.-T. Cheng, “Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro,” Life Sciences, vol. 71, no. 11, pp. 1321–1330, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. K.-L. Wong, P. Chan, H.-Y. Yang et al., “Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat,” Life Sciences, vol. 74, no. 19, pp. 2379–2387, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. W. Raasch, U. Schäfer, J. Chun, and P. Dominiak, “Biological significance of agmatine, an endogenous ligand at imidazoline binding sites,” British Journal of Pharmacology, vol. 133, no. 6, pp. 755–780, 2001. View at Google Scholar · View at Scopus
  31. S.-L. Hwang, I.-M. Liu, T.-F. Tzeng, and J.-T. Cheng, “Activation of imidazoline receptors in adrenal gland to lower plasma glucose in streptozotocin-induced diabetic rats,” Diabetologia, vol. 48, no. 4, pp. 767–775, 2005. View at Publisher · View at Google Scholar · View at Scopus