Antidiabetic Activity of Artemisia amygdalina Decne in Streptozotocin Induced Diabetic Rats
Table 1
(a) Effect of extracts of Artemisia amygdalina and glibenclamideon fasting blood glucose levels of rats. (b) Dose-dependent effect of hydroethanolic and methanolic extracts of Artemisia amygdalina and glibenclamideon fasting blood glucose levels of rats.
(a)
Groups
Serum glucose (mg/dL)
0th day
7th day
14th day
% variation
Normal
−1.51
Diabetic control
−13.88
Pet Ether extract (500 mg/kg b. w)
23.95
Hydroethanolic extract (500 mg/kg b. w)
54.07
Methanolic extract (500 mg/kg b. w)
43.93
Ethyl Acetate extract (500 mg/kg b. w)
29.84
Glibenclamide (3 mg/kg b. w)
48.09
The values are expressed as mean SEM; in each group. as compared with normal at the same time (one-way ANOVA followed by Dunnett’s multiple comparison test).
(b)
Groups
Serum Glucose (mg/dL)
0th day
7th day
14th day
% variation
Normal
1.80
Diabetic control
−11.75
Hydroethanolic extract (50 mg/kg b. w)
7.35
Hydroethanolic extract (100 mg/kg b. w)
18.76
Hydroethanolic extract (250 mg/kg b. w)
35.66
Hydroethanolic extract (500 mg/kg b. w)
56.88
Methanolic extract (50 mg/kg b. w)
4.06
Methanolic extract (100 mg/kg b. w)
10.56
Methanolic extract (250 mg/kg b. w)
24.35
Methanolic extract (500 mg/kg b. w)
45.09
Glibenclamide (3 mg/kg b. w)
47.55
The values are expressed as mean SEM; in each group. as compared with normal at the same time (one-way ANOVA followed by Dunnett’s multiple comparison test).
