Antidiabetic Activity of Artemisia amygdalina Decne in Streptozotocin Induced Diabetic Rats

Table 2

Effect of extracts of Artemisia amygdalina and glibenclamide on various biochemical parameters in rats.

Groups	Cholesterol; (mg/dL)	Triglycerides; (mg/dL)	LDL; (mg/dL)	Total protein; (g/dL)	Creatinine; (mg/dL)
Normal	50.59±2.77	62.83±2.46	83.35±3.22	7.11±0.30	0.69±0.05
Diabetic control	149.33±6.93	120.83±4.96	189.38±5.61	4.20±0.44	1.98±0.09
Hydroethanolic extract (250 mg/kg b. w)	84.32±3.67	95.74±5.54	132.45±3.35	5.75±0.29	1.18±0.05
Hydroethanolic extract (500 mg/kg b. w)	64.83±2.19^∗∗	75.66±4.87^∗∗	101.36±2.95^∗∗	6.12±0.32	0.88±0.08^∗∗
Methanolic extract (250 mg/kg b. w)	88.12±3.79	98.27±5.28	142.77±4.23	5.15±0.26	1.07±0.06
Methanolic extract (500 mg/kg b. w)	73.35±2.92^∗∗	84.43±6.44^∗∗	128.54±3.46^∗∗	6.67±0.28^∗∗	0.97±0.07^∗∗
Glibenclamide (3 mg/kg b. w)	60.83±2.73^∗∗	78.00±2.73^∗∗	92.37±3.67^∗∗	7.03±0.21^∗∗	0.78±0.04^∗∗

The values are expressed as mean ± SEM; 𝑛=5 in each group. ^∗∗𝑃<0.01 as compared with diabetic control at the same time (one-way ANOVA followed by Dunnett's multiple comparison test).