Antidiabetic Activity of Artemisia amygdalina Decne in Streptozotocin Induced Diabetic Rats

Table 6

(a) Effect of extracts of Artemisia amygdalina and glibenclamide on glucose tolerance of rats. (b) Dose-dependent effect of hydroethanolic and methanolic extracts of Artemisia amygdalina on glucose tolerance of rats.

(a)

Groups	Blood glucose level (mg/dL)
	0 min	30 min	60 min	90 min	120 min	% variation
Normal	82.35±3.44	147.58±4.11	133.60±5.05	125.34±6.40	118.36±3.53	43.72
Pet. ether extract (500 mg/kg b. w)	83.14±2.82	138.58±6.84	127.13±2.46	118.93±5.72	90.57±3.44	8.93
Ethyl acetate extract (500 mg/kg b. w)	80.76±2.10	142.48±3.53	125.71±6.40	112.91±5.90	94.64±6.35	17.18
Hydroethanolic extract (500 mg/kg b. w)	83.245±3.71	110.68±3.00^∗∗	97.79±3.49^∗∗	89.51±4.20^∗∗	79.51±4.52^∗∗	-4.48
Methanolic extract (500 mg/kg b. w)	80.47±3.22	122.27±4.20	112.72±4.38	98.61±5.99	86.44±4.65^∗∗	7.414
Glibenclamide (3 mg/kg b. w)	81.89±3.00	118.82±3.85^∗∗	107.82±3.67^∗∗	98.24±4.29^∗∗	82.56±4.11^∗∗	0.81

The values are expressed as mean ± SEM; 𝑛=5 in each group. ^∗∗𝑃<0.01 as compared with normal at the same time (one-way ANOVA followed by Dunnett’s multiple comparison test).

(b)

Groups	Blood glucose level (mg/dL)
	0 min	30 min	60 min	90 min	120 min	% variation
Normal	81.25±2.97	149.49±3.24	136.64±4.22	128.44±5.53	115.42±6.30	42.05
Hydroethanolic extract (50 mg/kg b. w)	82.41±3.23	145.45±4.67	131.24±2.35	122.46±4.86	112.25±4.33	36.20
Hydroethanolic extract (100 mg/kg b. w)	83.67±4.15	132.56±4.32	120.18±4.50	110.16±4.34	101.14±5.36	20.88
Hydroethanolic extract (250 mg/kg b. w)	81.54±5.25	121.24±2.96^∗∗	107.73±4.39^∗∗	96.64±3.74^∗∗	87.15±2.54^∗∗	6.88
Hydroethanolic extract (500 mg/kg b. w)	82.42±4.64	108.68±3.38^∗∗	96.21±3.44^∗∗	83.31±4.72^∗∗	72.15±5.42^∗∗	221212.46
Methanolic extract (50 mg/kg b. w)	83.66±4.12	150.52±3.35	140.88±3.48	128.25±2.78	118.26±3.35	41.35
Methanolic extract (100 mg/kg b. w)	82.52±4.45	141.65±3.22	129.42±3.68	116.27±3.85	105.51±5.22	27.86
Methanolic extract (250 mg/kg b. w)	83.24±5.24	131.57±4.38	116.21±5.12	106.35±4.62	95.23±4.95^∗∗	14.40
Methanolic extract (500 mg/kg b. w)	82.57±6.35	120.09±5.14	103.41±2.56	92.35±3.44	81.13±2.55^∗∗	1.74
Glibenclamide (3 mg/kg b. w)	80.68±2.75	116.78±5.83^∗∗	104.23±6.73^∗∗	94.16±5.25^∗∗	83.25±4.75^∗∗	3.18

The values are expressed as mean ± SEM; 𝑛=5 in each group. ^∗∗𝑃<0.01 as compared with normal at the same time (one-way ANOVA followed by Dunnett's multiple comparison test).