A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin

Table 1

Antiviral activities of Curcuma longa L. and curcumin.

Virus	Antiviral substances	Description of antiviral activity type	Reference
HIV	Curcumin	Inhibition of HIV-1 LTR-directed gene expression	[24]
	Curcumin, reduced curcumin, allyl-curcumin, tocopheryl-curcumin	Inhibition of Tat-mediated transactivation of HIV-1 LTR	[25]
	Curcumin, curcumin boron complexes	Inhibition of HIV-1 and HIV-2 proteases	[26]
	Curcumin	Inhibition of HIV-1 Integrase	[27]
	Curcumin	Inhibition of Tat protein acetylation	[28]
	Curcumin	No antiviral effect in clinical trial	[29]
Influenza	Curcumin	Inhibition of haemagglutination	[30]
HSV-1	Curcumin, gallium-curcumin, Cu-curcumin	Reduction of HSV-1 replication	[31, 32]
HSV-2	Curcumin	Significant protection in mouse model	[33]
Coxsackievirus	Curcumin	Replication inhibition through UPS dysregulation	[34]
HBV	Aqueous extract	Suppression of HBV replication by increasing the p53 level	[35]
HCV	Curcumin	Decrease of HCV replication by suppressing the Akt-SREBP-1 pathway	[36]
HPV	Curcumin	Inhibition expression of viral oncoproteins of E6 and E7	[37]
HPV	Curcumin	Downregulation effect on the transcription of HPV-18	[38]
JEV	Curcumin	Reduction in production of infective viral particles	[39]
HTLV-1	Curcumin	Downregulation of JunD protein in HTLV-1-infected T-cell lines	[40]