Genome-Wide Uncovering of STAT3-Mediated miRNA Expression Profiles in Colorectal Cancer Cell Lines
Figure 2
The miRNA expression levels from deep sequencing and validation with qRT-PCR. (a) The scatter plot shows the expression levels of known miRNAs in SW480/siRNA-control and SW480/STAT3-siRNA cells. Blue dots: equally expressed miRNAs between SW480/siRNA-control and SW480/STAT3-siRNA. Red dots: miRNAs in SW480/STAT3-siRNA are upexpressed compared to SW480/siRNA-control (adjusted ). Green dots: miRNAs in SW480/STAT3-siRNA are downexpressed compared to SW480/siRNA-control (adjusted ). (b) The validation of selected up- and downexpressed known miRNAs indicates a strong correlation (Pearson’s correlation = 0.97) between deep sequencing data and the qRT-PCR results.
