BioMed Research International / 2014 / Article / Tab 5

Research Article

Drug Repositioning Discovery for Early- and Late-Stage Non-Small-Cell Lung Cancer

Table 5

Summary of the top ten pathways returned by REACTOME using CPDB for early- and late-stage NSCLC.

Early-stage NSCLC
Pathway nameEffective size% of overlap value

Cell surface interactions at the vascular wall946.4%
Nephrin interactions2313%
Hemostasis4631.5%
Glycolysis2810.7%
Gluconeogenesis329.4%
PECAM1 interactions1216.7%0.00022
Integrin cell surface interactions664.5%0.00025
Glucose metabolism674.5%0.00026
Regulation of signaling by CBL1811.1%0.00052
CD28 dependent PI3K/Akt signaling219.5%0.00071

Late-stage NSCLC
Pathway nameEffective size% of overlap value

Cell cycle4425.9%
Cell cycle, mitotic3556.8%
Mitotic M-M/G1 phases2148.4%
APC/C-mediated degradation of cell cycle proteins3826.3%
Regulation of mitotic cell cycle3826.3%
M phase1838.2%
Mitotic prometaphase11010.9%
Mitotic anaphase1309.2%
Mitotic metaphase and anaphase1319.2%
Resolution of sister chromatid cohesion10110.9%