BioMed Research International / 2014 / Article / Tab 7

Research Article

Drug Repositioning Discovery for Early- and Late-Stage Non-Small-Cell Lung Cancer

Table 7

Summary of top pathways returned by KEGG using CPDB for early- and late-stage cancer.

Early-stage NSCLC
TermEffective size% of overlap value

Leukocyte transendothelial migration1183.4%
Glycolysis/gluconeogenesis664.5%0.000250
Epithelial cell signaling in Helicobacter pylori infection684.4%0.000273
HIF-1 signaling pathway1062.8%0.00100
Tight junction1342.2%0.00197
Cell adhesion molecules (CAMs)1472.0%0.00257

Late-stage NSCLC
TermEffective size% of overlap value

Cell cycle1249.7%
Oocyte meiosis1107.3%
Progesterone-mediated oocyte maturation867.0%
DNA replication368.3%0.00100
Epstein-Barr virus infection2032.5%0.00512
Viral carcinogenesis2062.4%0.00544
p53 signaling pathway684.4%0.00620
Measles1343.0%0.00630
Hepatitis B1462.7%0.00849