196034.fig.001a
(a)
196034.fig.001b
(b)
Figure 1: The concept of synthetic lethality. (a) If just one of the SL pair genes is mutated, then the cell is alive. A/B wild type, a/b-mutated genes; (b) mutation/inhibition of one gene or both genes of a SL gene pair leads to different cell fates [2].