Crude Extracts from Lycium barbarum Suppress SREBP-1c Expression and Prevent Diet-Induced Fatty Liver through AMPK Activation
LBP prevents fatty liver by activation of AMPK and inhibition of SREBP-1c in HFD-fed mice. (a) Protein expression levels of p-AMPK, nuclear SREBP-1c, p-ACC, and FAS in liver tissue. Data was normalized to β-actin, #, and ##, compared to HFD group, respectively. (b) The mRNA expression of UCP1 and PGC-1α in brown adipose tissue. Data was normalized to GAPDH and #, compared to HFD group, respectively. (c) Immunohistochemical analysis detected the distribution of SREBP-1c and FAS in liver sections (×400 magnification).
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