Snake Venom L-Amino Acid Oxidases: Trends in Pharmacology and Biochemistry

Table 5

Cytotoxic and apoptotic effects of L-amino acid oxidases isolated from snake venom.

Venom	Toxin	Cell line (DNA)	Concentration and treatment time	Reference
Lachesis  muta	LmLAAO	LL-24, AGS, MCF-7, and HUTU	1.17–75 𝜇g/mL for 24 h	[15]
Bothrops  leucurus	Bl-LAAO	MKN-45 and RKO	0.1–20 μg/mL for 24 h	[17]
Bungarus  fasciatus	BF-LAAO	A549	0.03–3.0 μg/mL for 12 h	[55]
Bothrops  atrox	LAAO	PC12, B16F10, HL-60, and Jurkat	5–50 μg/mL for 4 h	[45]
Bothrops  moojeni	BmooLAAO-I	HL-60	8–16 μg/mL for 12 h	[66]
Agkistrodon  acutus	ACTX-8	HeLa	20 μg/mL for 12–48 h	[29]
Bothrops  pirajai	BpirLAAO-I	Fago M13mp18	1–20 μg/mL for 24 h	[32]
Vipera  berus  berus	V.  berus  berus LAAO	HeLa and K562	2.5–10 μg/mL for 7–24 h	[33]
Trimeresurus  flavoviridis	OHAP-1	RBR17T and C6	2.5 and 5 μg/mL for 24 h	[48]
Eristicophis  macmahoni	LNV-LAO	MM6	25–100 μg/mL for 18 h	[83]
Agkistrodon  contortrix  laticinctus	ACL LAO	HL-60	2.5–100 μg/mL for 16 h	[75]