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BioMed Research International
Volume 2014, Article ID 198697, 5 pages
http://dx.doi.org/10.1155/2014/198697
Research Article

IDH1R132H Mutation Increases U87 Glioma Cell Sensitivity to Radiation Therapy in Hypoxia

1Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l’Institut du Cerveau et de la Moëlle épinière (CRICM), UMR-S975, 75013 Paris, France
2INSERM, U 975, 75013 Paris, France
3CNRS, UMR 7225, 75013 Paris, France
4CNRS, UMR 6301 ISTCT, CERVOxy group, GIP CYCERON, Boulevard Henri Becquerel, BP 5229, 14074 Caen cedex, France
5Université de Caen Basse-Normandie, UMR 6301 ISTCT, 14000 Caen, France
6CEA, DSV/I2BM, UMR 6301 ISTCT, 14000 Caen, France
7CHU de Caen, Service de Neurologie, Boulevard Côte de Nacre, 14000 Caen, France
8AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie 2, 75013 Paris, France
9Service de Neurologie 2, Groupe Hospitalier Pitié-Salpêtrière, 75651 Paris Cedex 13, France

Received 12 February 2014; Accepted 6 April 2014; Published 7 May 2014

Academic Editor: Andrea Pace

Copyright © 2014 Xiao-Wei Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. W. Parsons, S. Jones, X. Zhang et al., “An integrated genomic analysis of human glioblastoma multiforme,” Science, vol. 321, no. 5897, pp. 1807–1812, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Sanson, Y. Marie, S. Paris et al., “Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas,” Journal of Clinical Oncology, vol. 27, no. 25, pp. 4150–4154, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. M. J. Van Den Bent, H. J. Dubbink, Y. Marie et al., “IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group,” Clinical Cancer Research, vol. 16, no. 5, pp. 1597–1604, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Houillier, X. Wang, G. Kaloshi et al., “IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas,” Neurology, vol. 75, no. 17, pp. 1560–1566, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. M. J. van den Bent, A. A. Brandes, M. J. B. Taphoorn et al., “Adjuvant PCV chemotherapy in newly diagnosed anaplastic oligodendroglioma-long term follow-up of EORTC Brain Tumor Group study 26951,” Journal of Clinical Oncology, vol. 31, no. 3, pp. 344–350, 2013. View at Publisher · View at Google Scholar
  6. J. G. Cairncross, M. Wang, R. B. Jenkins et al., “Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH,” Journal of Clinical Oncology, vol. 32, no. 8, pp. 783–790, 2014. View at Publisher · View at Google Scholar
  7. L. Dang, D. W. White, S. Gross et al., “Cancer-associated IDH1 mutations produce 2-hydroxyglutarate,” Nature, vol. 462, no. 7274, pp. 739–744, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Lu, P. S. Ward, G. S. Kapoor et al., “IDH mutation impairs histone demethylation and results in a block to cell differentiation,” Nature, vol. 483, no. 7390, pp. 474–478, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Turcan, D. Rohle, A. Goenka et al., “IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype,” Nature, vol. 483, no. 7390, pp. 479–483, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Xu, H. Yang, Y. Liu et al., “Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases,” Cancer Cell, vol. 19, no. 1, pp. 17–30, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Koivunen, S. Lee, C. G. Duncan et al., “Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation,” Nature, vol. 483, no. 7390, pp. 484–488, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. L. B. C. Bralten, N. K. Kloosterhof, R. Balvers et al., “IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo,” Annals of Neurology, vol. 69, no. 3, pp. 455–463, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. H. L. Jin, Y. K. Sung, S. K. In, and J.-W. Park, “Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase,” Journal of Biological Chemistry, vol. 282, no. 18, pp. 13385–13394, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Shi, H. Zuo, L. Ni et al., “An IDH1 mutation inhibits growth of glioma cells via GSH depletion and ROS generation,” Neurological Sciences. In press.
  15. I. V. Mohrenz, P. Antonietti, S. Pusch et al., “Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death,” Apoptosis, vol. 18, pp. 1416–1425, 2013. View at Publisher · View at Google Scholar
  16. S. Li, A. P. Chou, W. Chen et al., “Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation,” Neuro-Oncology, vol. 15, pp. 57–68, 2013. View at Publisher · View at Google Scholar
  17. S. Zhao, Y. Lin, W. Xu et al., “Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α,” Science, vol. 324, no. 5924, pp. 261–265, 2009. View at Publisher · View at Google Scholar · View at Scopus