Research Article

Prenatal Maternal Stress Predicts Childhood Asthma in Girls: Project Ice Storm

Table 5

Final logistic regression models predicting asthma-related outcomes.

Models S.E.Exp( )90% CI for Exp( )

(1) Lifetime wheezing
Constant−0.1260.7160.882
Life events (11.5 years)0.369*0.2271.4470.9972.100
Sex (0 = male)−1.587*0.9180.2040.0450.926
Subjective distress−0.0300.0380.9710.9121.033
Subjective distress × sex0.137*0.0721.1471.0191.291

(2) Doctor-diagnosed asthma
Constant−1.655*0.8910.191
Life events (6 months)0.237*0.1211.2671.039 1.545
Sex (0 = male)−2.270*1.1810.1030.015 0.721
Subjective distress−0.126*0.0720.8810.783 0.992
Subjective distress × sex0.214**0.0881.2381.071 1.431

(3) Corticosteroid utilization
Constant−0.9990.8230.368
Life events (11.5 years)0.769**0.2902.1581.338 3.479
Parental asthma history−1.661*0.9340.1900.041 0.883
Sex (0 = male)−1.7591.1030.1720.028 1.058
Subjective distress−0.0570.0470.9450.874 1.021
Subjective distress × sex0.173**0.0831.1881.0371.362

; .
Procedure: analyses were conducted on the entire sample ( ). Three distinct hierarchical logistic regression models were tested. Blocks of potential covariates used stepwise procedure with a value of 0.10 as criterion to enter a variable into the model. Independent variables were forced into the model. Nonsignificant predictors were trimmed from the final model. Odds ratios (OR) and confidence intervals (CI) for interaction terms between stress measures and gender were calculated as per Kleinbaum and Klein [68].