Amelioration of Colitis in Mouse Model by Exploring Antioxidative Potentials of an Indigenous Probiotic Strain of Lactobacillus fermentum Lf1
Figure 4
Histological examination and scores of different groups of mice. (a) Histological examination of noncolitis control group, noncolitis (Lf1) control, colitis group, and Lf1-treated group of mice. A-B: NC-PBS (noncolitis control), showing normal mucosal and epithelial layer along with intact glands with no sign of inflammation, infiltration, ulceration, and cryptitis; C-D: NC-Lf1 (noncolitis (Lf1) control), showing normal histology of noncolitis (Lf1) control similar to noncolitis control; E–H: C-PBS (colitis control), showing severity of colitis in colitis control group. (1) Inflammation infiltrate (lymphocytes and neutrophils), (2) gland destruction, (3) cryptitis, (4) loss of entire crypt with erosion of surface epithelium, and I-L: C-Lf1 (colitis-Lf1 treatment groups), showing normalization of histological score in colitis- (Lf1) treated group with no cryptitis, no ulceration, and minimal-to-moderate infiltration. (b) Histological scores/changes induced in different mice colon in different mice groups in different treatments. NC-PBS: noncolitis control; NC-Lf1: noncolitis (Lf1) control; C-PBS: colitis control; and C-Lf1: colitis-Lf1 treatment groups. Data are significantly different within the group (, Bonferroni post hoc test). The data for different groups were reported as mean ± standard deviation.
