Thymic Epithelial Cell Development and Its Dysfunction in Human Diseases

Table 1

The major differences between cTECs and mTECs.

	cTECs	mTECs
Location	Cortex	Medulla
Cytokeratin expression	K8, K18	K5, K14
Surface marker	Ly51, CD205	UEA-1, CD80
Maturation	MHCII^hi, 𝛽5t	MHCII^hi, CD80^hi, Aire, TRAs
Proteases	𝛽5t, Cathepsin-L, TSSP	IFN-𝛾-induced 𝛽5i, 𝛽1i, 𝛽2i
		Cathepsin-L, S
T cell selection	Positive	Negative

hiHigh expression; TSSP: thymus-specific serine protease; TRAs: tissue restricted antigens.