Characterization of Silk Fibroin Modified Surface: A Proteomic View of Cellular Response Proteins Induced by Biomaterials

Table 4

The identified peptides and gene ontologies of CD44.

Accession number	Protein name	Subcellular location	Biological process	Molecular function
P16070	CD44	Membrane, cytoplasm, Golgi apparatus	Cell adhesion, cellular response to fibroblast growth factor stimulus	Blood group antigen, receptor, collagen binding

CD44 is the receptor for hyaluronic acid (HA) and mediates cell-cell and cell-matrix interactions through its affinity for HA and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs).