Expression of Phosphocitrate-Targeted Genes in Osteoarthritis Menisci

Table 2

Genes classified in inflammatory response and angiogenesis.

Biological process	Gene name	Gene ID	Differ expre (fold)^*	Description
Inflammatory response
	CCL20	NM_004591	−103.53	Chemokine (C-C motif) ligand 20
	CCL5	NM_002985	−3.54	Chemokine (C-C motif) ligand 5
	CCR5	NM_000579	−2.03	Chemokine (C-C motif) receptor 5
	CXCL3	NM_002090	−10.03	Chemokine (C-X-C motif) ligand 3
	CXCL2	M57731	−2.94	Chemokine (C-X-C motif) ligand 2
	CXCL1	NM_001511	−3.01	Chemokine (C-X-C motif) ligand 1
	CXCL9	NM_002416	−2.65	Chemokine (C-X-C motif) ligand 9
	CXCL13	NM_006419	−2.62	Chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
	CXCR4	AF348491	−2.63	Chemokine (C-X-C motif) receptor 4
	PTGS2	AY151286	−34.01	Prostaglandin-endoperoxide synthase 2
	IL6	NM_000600	−32.07	Interleukin 6 (interferon, beta 2)
	IL23A	AF043179	−16.44	Enhancer of polycomb homolog 1 (Drosophila)
	IL8	NM_000584	−8.17	Interleukin 8
	IL1B	NM_000576	−2.28	Interleukin 1, beta
	IL1RN	BE563442	−2.80	Interleukin 1 receptor antagonist
	S100A8	NM_002964	−16.53	S100 calcium binding protein A8
	S100A9	NM_002965	−2.79	S100 calcium binding protein A9
	LBP	M35533	−11.36	Lipopolysaccharide binding protein
	APOE	NM_000041	−9.23	Apolipoprotein E
	FABP4	AI766029	−6.98	Fatty acid binding protein 4, adipocyte
	LYZ	U25677	−6.37	Lysozyme (renal amyloidosis)
	ITIH4	AI004137	−6.33	Inter-alpha (globulin) inhibitor H4
	BDKRB2	NM_000623	−6.01	Bradykinin receptor B2
	TLR8	AW872374	−5.55	Toll-like receptor 8
	TLR7	NM_016562	−3.34	Toll-like receptor 7
	TLR5	AF051151	−3.00	Toll-like receptor 5
	TLR4	NM_003266	−2.40	Toll-like receptor 4
	TLR2	NM_003264	−2.20	Toll-like receptor 2
	TLR1	AL050262	−2.66	Toll-like receptor 1
	AOX1	AB046692	−5.34	Aldehyde oxidase 1
	FCER1A	BC005912	−5.19	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
	CFD	NM_001928	−4.99	Complement factor D (adipsin)
	CFI	BC020718	−3.37	Complement factor I
	CFB	NM_001710	−2.39	Complement factor B
	C3	NM_000064	−2.32	Complement component 3
	CR1	AI052659	−2.24	Complement component (3b/4b) receptor 1 (Knops blood group)
	C1RL	NM_016546	−2.01	Complement component 1, r subcomponent-like
	C1QA	NM_015991	−2.20	Complement component 1, q subcomponent, A chain
	C1QB	NM_000491	−2.10	Complement component 1, q subcomponent, B chain
	AOAH	NM_001637	−4.89	Acyloxyacyl hydrolase (neutrophil)
	AGT	NM_000029	−4.66	Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
	BMP6	NM_001718	−4.48	Bone morphogenetic protein 6
	PLA2G7	M80436	−3.95	Platelet-activating factor receptor
	FOS	BC004490	−3.95	V-fos FBJ murine osteosarcoma viral oncogene homolog
	CD40	NM_001250	−3.68	CD40 molecule, TNF receptor superfamily member 5
	CD163	NM_004244	−3.68	CD163 molecule
	CD14	NM_000591	−3.25	CD14 molecule
	MASP1	AI274095	−3.67	Mannan-binding lectin serine peptidase 1
	F11R	AF191495	−3.16	F11 receptor
	ITGB2	L78790	−2.98	Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
	NLRC4	NM_021209	−2.92	NLR family, CARD domain containing 4
	AIF1	U19713	−2.76	Allograft inflammatory factor 1
	ALOX5	NM_000698	−2.71	Arachidonate 5-lipoxygenase
	NOD1	AF126484	−2.66	Nucleotide-binding oligomerization domain containing 1
	JMJD3	AI830331	−2.46	Jumonji domain containing 3, histone lysine demethylase
	SIGLEC1	NM_023068	−2.46	Sialic acid binding Ig-like lectin 1, sialoadhesin
	TNFAIP6	AW188198	−2.37	Tumor necrosis factor, alpha-induced protein 6
	LY86	NM_004271	−2.36	Lymphocyte antigen 86
	AOC3	NM_003734	−2.31	Amine oxidase, copper containing 3 (vascular adhesion protein 1)
	TNFRSF1B	NM_001066	−2.21	Tumor necrosis factor receptor superfamily, member 1B
	BCL6	S67779	−2.17	B-cell CLL/lymphoma 6 (zinc finger protein 51)
	CLEC7A	AF313468	−2.12	C-type lectin domain family 7, member A
	CDO1	NM_001801	−2.11	Cysteine dioxygenase, type I
	NFATC4	AI806528	−2.04	NF of activated T-cells, cytoplasmic, calcineurin-dependent 4
	SERPINA3	NM_001085	5.20	Serpin peptidase inhibitor, clade A, member 3
	SERPINA1	AF119873	3.58	Serpin peptidase inhibitor, clade A, member 1
	C4BPA	NM_000715	3.34	Complement component 4 binding protein, alpha
	FN1	AJ276395	3.03	Fibronectin 1
	B4GALT1	D29805	2.99	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1
	GPR68	AI805006	2.40	G protein-coupled receptor 68
	C7	NM_000587	2.36	Complement component 7
	ANXA1	AU155094	2.23	Annexin A1
	KLKB1	NM_000892	2.21	Cytochrome P450, family 4, subfamily V, polypeptide 2
Angiogenesis
	PTGS2	AY151286	−34.00	Prostaglandin-endoperoxide synthase 2
	BAI3	NM_001704	−33.48	Brain-specific angiogenesis inhibitor 3
	IL6	NM_000600	−32.08	Interleukin 6 (interferon, beta 2)
	IL8	NM_000584	−8.18	Interleukin 8
	IL1B	NM_000576	−2.28	Interleukin 1, beta
	SFRP1	AF017987	−17.55	Secreted frizzled-related protein 1
	ANGPTL4	AF169312	−11.43	Angiopoietin-like 4
	ANGPT2	BE501356	−2.56	Angiopoietin 2
	EREG	NM_001432	−8.60	Epiregulin
	VEGFA	M27281	−7.91	Vascular endothelial growth factor A
	VASH1	AU152507	−4.24	Vasohibin 1
	FLT1	U01134	−3.62	Fms-related tyrosine kinase 1
	PTPRB	AL080103	−3.48	Protein tyrosine phosphatase, receptor type, B
	FGF10	NM_004465	−3.34	Fibroblast growth factor 10
	LIF	NM_002309	−3.16	Leukemia inhibitory factor (cholinergic differentiation factor)
	BTG1	BC009050	−3.11	B-cell translocation gene 1, anti-proliferative
	DLL4	AB036931	−2.85	Delta-like 4 (Drosophila)
	SOX17	NM_022454	−2.45	SRY (sex determining region Y)-box 17
	EPAS1	NM_001430	−2.43	Endothelial PAS domain protein 1
	CTNNB1	AB062292	−2.35	Catenin (cadherin-associated protein), beta 1, 88 kDa
	TGFBR2	NM_003242	−2.35	Transforming growth factor, beta receptor II (70/80 kDa)
	TYMP	NM_001953	−2.34	Thymidine phosphorylase
	C3	NM_000064	−2.32	Complement component 3
	NRP1	AF280547	−2.19	Neuropilin 1
	NOTCH4	AI743713	−2.17	Notch homolog 4 (Drosophila)
	TSPAN12	AI056699	−2.16	Tetraspanin 12
	ADAM8	NM_001109	−2.15	ADAM metallopeptidase domain 8
	RHOB	AI263909	−2.12	Ras homolog gene family, member B
	HHEX	NM_001529	−2.12	Hematopoietically expressed homeobox
	THBS1	BF055462	−2.05	Thrombospondin 1
	KDR	NM_002253	−2.03	Kinase insert domain receptor (a type III receptor tyrosine kinase)
	GREM1	NM_013372	15.86	Gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
	FGFR2	AB030078	4.49	Fibroblast growth factor receptor 2
	FGF1	X59065	2.39	fibroblast growth factor 1 (acidic)
	FGF18	AI798863	2.33	Fibroblast growth factor 18
	COL8A2	AI806793	4.46	Collagen, type VIII, alpha 2
	COL8A1	BE877796	3.30	Collagen, type VIII, alpha 1
	ARHGAP22	NM_021226	4.45	Rho GTPase activating protein 22
	TNFRSF12A	NM_016639	3.23	Tumor necrosis factor receptor superfamily, member 12A
	CSPG4	BE857703	3.14	Chondroitin sulfate proteoglycan 4
	WNT5B	NM_030775	3.10	Wingless-type MMTV integration site family, member 5B
	FN1	AJ276395	3.03	Fibronectin 1
	SFRP2	AF311912	3.00	Secreted frizzled-related protein 2
	B4GALT1	D29805	2.99	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1
	ANGPT1	NM_001146	2.62	Angiopoietin 1
	MFGE8	BC003610	2.39	Milk fat globule-EGF factor 8 protein
	TGFB2	NM_003238	2.36	Transforming growth factor, beta 2
	CYR61	NM_001554	2.30	Cysteine-rich, angiogenic inducer, 61
	MEOX2	NM_005924	2.15	Mesenchyme homeobox 2
	PLXDC1	NM_020405	2.09	Plexin domain containing 1
	TBXA2R	NM_001060	2.09	Thromboxane A2 receptor

Negative number indicates decreased expression and positive number indicates increased expression (fold change).