Expression of Phosphocitrate-Targeted Genes in Osteoarthritis Menisci

Table 4

Differential expression of selected genes.

Gene name	Gene ID	Differential expression^* microarray	Differential expression^** microarray	Differential expression^*** real-time RT-PCR
CCL5	NM_002985	−3.54	−6.28	−3.69
CCR5	NM_000579	−2.03	−2.95
FCGR3B	NM_000570	−6.49	−2.09
FCGR2B	M31933	−3.45	−3.72
IL6	NM_000600	−32.07	−1.85
IL7R	BE217880	−3.31	−11.0	−2.85
IL8	NM_000584	−8.17	−2.25
IL23A	M15564	−7.89	−8.98
LILRB1	NM_006669	−4.33	−3.06
LILRB3	AF009634	−4.23	−3.38
TLR8	AW872374	−5.55	−3.55
TLR7	NM_016562	−3.34	−2.54
HLA-DRB1	AJ297586	−2.72	−3.41	−1.97
S100A8	NM_002964	−16.53	−9.95
S100A9	NM_002965	−2.79	−4.70
PTPRC	NM_002838	−5.88	−2.85
SYK	NM_003177	−2.42	−2.99
BMP6	NM_001718	−4.48	−3.00
CPA3	NM_001870	−15.23	−9.37
CPM	BE878495	−3.17	−2.74
ADAMTS5	BI254089	−2.84	−1.98	−2.65
ADAM28	NM_021778	−14.27	−3.59
MMP10	NM_002425	−2.41	−1.56
MMP1	NM_002421	−2.15	−1.83	−2.01
FGFR3	NM_000142	2.40	1.52
SOX-9	NM_000346	2.00	1.70
POSTN	AW137148	5.57	2.76
COL2A1	X06268	21.29	1.76	3.11
COL11A1	J04177	9.86	2.29
COL1A1	AI743621	2.59	1.79
ACAN	NM_001135	9.17	2.02	2.65

Negative number indicates decreased expression and positive number indicates increased expression (fold change).
^**Second microarray using different RNA samples extracted from meniscal explants derived from a different OA patient.
^***Results of real-time RC-PCR.