Review Article

A Network Meta-Analysis on Randomized Trials Focusing on the Preventive Effect of Statins on Contrast-Induced Nephropathy

Table 2

Patient and procedural features.

First authorYearExperimental therapy Control therapy Contrast typeMedian contrast volumeAge (years)Diabetes mellitusBaseline serum creatinine (mg/dL)

Cao [8]2012Atorvastatin 40 mg/day started 3 days before angioplasty followed by atorvastatin 20 mg/dayAtorvastatin 20 mg/dayNA1616320%NA

Han [4]2013Rosuvastatin 10 mg/day from 2 days before to 3 days after contrastNo statinIodixanol11561100%1.1

Jo [9]2008Simvastatin 40 + 40 mg before angiography followed by simvastatin 40 + 40 mg afterwardsPlaceboIodixanol1826526%1.2

Jo [10]2014Atorvastatin 80 mg before angiography followed by atorvastatin 80 mg/day for 5 days and then 10 mg/dayAtorvastatin 10 mg/dayNANA6026%1.1

Kaya [11]2013Atorvastatin 80 mg before angiographyRosuvastatin 40 mg before angiographyIopromide1536320%0.9

Leoncini [12]2014Rosuvastatin 40 mg at admission followed by 20 mg/dayNo statinIodixanol2616621%1.0

Li [13]2012Atorvastatin 80 mg at admission followed by atorvastatin 40 mg after angiographyPlaceboIopromide1026628%0.9

Li [14]2014Atorvastatin 40 mg before angiography, followed by atorvastatin 40 mg/dayAtorvastatin 20 mg/dayIopamidol1866124%0.9

zhan [15]2010Atorvastatin 80 mg before angiography, followed by atorvastatin 80 mg 48 hours after contrast administrationNo statinIopamidol955516%0.8

Patti [16]2011Atorvastatin 80 mg 12 hrs before angiography; further 40 mg preprocedure (2 hrs before), followed by atorvastatin 40 mg/dayPlaceboIobitridol2116627%1.0

Quintavalle [17]2012Atorvastatin 80 mg (within 24 hrs before contrast exposure), followed by atorvastatin 20 mg/dayNo statinIodixanol1807041%1.3

Toso [18]2010Atorvastatin 80 mg 48 hours before and 48 hours after contrast administrationPlaceboIodixanol1577521%1.2

Xinwei [19]2009Simvastatin 80 mg from admission to day before PCI, followed by simvastatin 20 mg/daySimvastatin 20 mg/dayIodixanol or iohexol2336521%0.8

Zhou [20]2009Atorvastatin 80 mg/day before the procedure, 10 mg/day for 6 days after procedureAtorvastatin 10 mg/day for 7 daysIopamidol1166120%1.1

NA = not available or applicable.