BioMed Research International / 2014 / Article / Tab 2

Review Article

High-Throughput Analysis of Ovarian Granulosa Cell Transcriptome

Table 2

Gene expression profiling of human granulosa and cumulus cells.

Type of cell Assay Gene profiles/outcomeReference

Granulosa cells from aspirated follicular fluidMicroarrayFDX1, CYP19A1, CDC42, SERPINE2, and  3bHSD1, positively correlated with oocyte developmental competenceHamel et al., 2008 [16]
Cumulus cells Whole Human Genome Oligo Microarray 4x44K (Agilent Technologies)RGS2, related to oocyte developmental competenceFeuerstein et al., 2012 [17]
Cumulus cellsAffymetrix HG-U133 Plus 2.0 arrayBCL2L11, PCK1, and  NFIB, significantly correlated with embryo potentialAssou et al., 2008 [18]
Cumulus cells from gonadotropin stimulated patientsHuman Genome U133 Plus 2.0 microarraysNPY1R, GM2A, GREM1 OSBPL6, STC2, and PTX3,  correlated with embryo qualityAssou et al., 2013 [19]