Research Article
Polymorphism of XRCC1, XRCC3, and XPD Genes and Risk of Chronic Myeloid Leukemia
Table 1
Genotype distribution and allele frequency for the five polymorphisms analyzed in patients with CML and controls.
| | Polymorphism | | CML patients
(%) | Controls
(%) | OR (95% CI)
CML versus controls | value
CML versus controls |
| | XRCC1 Arg194Trp | Arg/Arg | 119 (76.3) | 129 (71.7) | — | — | | Arg/Trp | 31 (19.9) | 45 (25.0) | 0.75 (0.44–1.26) | 0.294 | | Trp/Trp | 6 (3.8) | 6 (3.3) | 1.08 (0.34–3.45) | 1.00 | | Arg/Trp + Trp/Trp | 37 (23.7) | 51 (28.3) | 0.78 (0.48–1.28) | 0.384 | | Arg allele | 269 (86.2) | 303 (84.2) | — | — | | Trp allele | 43 (13.8) | 57 (15.8) | 0.85 (0.55–1.31) | 0.515 |
| | XRCC1 Arg280His | Arg/Arg | 82 (52.7) | 112 (62.2) | — | — | | Arg/His | 64 (41.0) | 58 (32.2) | 1.51 (0.96–2.38) | 0.083 | | His/His | 10 (6.3) | 10 (5.6) | 1.37 (0.54–3.43) | 0.636 | | Arg/His + His/His | 74 (47.4) | 68 (37.8) | 1.48 (0.96–2.29) | 0.077 | | Arg allele | 228 (73.1) | 282 (78.3) | — | — | | His allele | 84 (26.9) | 78 (21.7) | 1.33 (0.93–1.89) | 0.124 |
| | XRCC1 Arg399Gln | Arg/Arg | 71 (45.5) | 91 (50.6) | — | — | | Arg/Gln | 69 (44.2) | 73 (40.5) | 1.21 (0.77–1.91) | 0.421 | | Gln/Gln | 16 (10.3) | 16 (8.9) | 1.28 (0.59–2.74) | 0.563 | | Arg/Gln + Gln/Gln | 85 (54.5) | 89 (49.4) | 1.22 (0.79–1.88) | 0.382 | | Arg allele | 211 (67.6) | 255 (69.7) | — | — | | Gln allele | 101 (32.4) | 105 (30.3) | 1.16 (0.84–1.62) | 0.401 |
| | XPD Lys751Gln | Lys/Lys | 51 (32.7) | 82 (45.6) | — | — | | Lys/Gln | 77 (49.4) | 79 (43.9) | 1.57 (0.98–2.51) | 0.075 | | Gln/Gln | 28 (17.9) | 19 (10.5) | 2.37 (1.20–4.67) | 0.016 | | Lys/Gln + Gln/Gln | 105 (67.3) | 98 (54.4) | 1.72 (1.10–2.69) | 0.019 | | Lys allele | 179 (57.4) | 243 (67.5) | — | — | | Gln allele | 133 (42.6) | 117 (32.5) | 1.543 (1.13–2.11) | 0.008 |
| | XRCC3 Thr241Met | Thr/Thr | 64 (41.0) | 85 (47.2) | — | — | | Thr/Met | 70 (44.9) | 79 (43.9) | 1.17 (0.74–1.86) | 0.561 | | Met/Met | 22 (14.1) | 16 (8.9) | 1.82 (0.88–3.76) | 0.105 | | Thr/Met + Met/Met | 92 (58.9) | 95 (52.8) | 1.28 (0.83–1.98) | 0.272 | | Thr allele | 198 (63.5) | 249 (69.2) | — | — | | Met allele | 114 (36.5) | 111 (30.8) | 1.29 (0.94–1.78) | 0.120 |
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